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Sphingosine Kinase 1 Participates In The Activation, Proliferation And Survival Of Chronic Lymphocytic Leukemia Cells
(Ferrata Storti Foundation, 2017-03)
Sphingosine kinases (SKs) have received the most attention as important enzymes in cancer biology. They participate in the regulation of bioactive sphingolipid metabolism by producing sphingosine-1 phosphate (S1P) which ...
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
(Nature Publishing Group, 2010-06)
Tumour-necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is a key component in NF-κB signalling triggered by TNF-α1, 2. Genetic evidence indicates that TRAF2 is necessary for the polyubiquitination of receptor ...
Sphingosine-1-Phosphate Is a Key Regulator of Proliferation and Differentiation in Retina Photoreceptors
(Association for Research in Vision and Ophthalmology, 2009-09)
PURPOSE. Identifying the cues required for survival and development of photoreceptors is essential for treating retina neurodegenerations. We previously established that glial derived neurotrophic factor (GDNF) stimulates ...
The expression of Sphingosine kinase-1 in head and neck carcinoma
(Karger, 2010-10)
Sphingosine kinase-1 (SPHK1) modulates the proliferation, apoptosis and differentiation of keratinocytes through the regulation of ceramide and sphingosine-1-phosphate levels. However, studies on the expression of SPHK1 ...
The Expression of Sphingosine Kinase-1 in Head and Neck Carcinoma
(Karger, 2010-07)
Sphingosine kinase-1 (SPHK1) modulates the proliferation, apoptosis and differentiation of keratinocytes through the regulation of ceramide and sphingosine-1-phosphate levels. However, studies on the expression of SPHK1 ...
Human eosinophil chemotaxis and selective in vivo recruitment by sphinglosine 1-phosphate
(Natl Acad SciencesWashingtonEUA, 2004)
Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
(Macmillan Publishers Limited, 2015)
Sphingosine-1 phosphate: A new modulator of immune plasticity in the tumor microenvironment
(Frontiers Media S.A., 2016-10-17)
In the last 15 years, increasing evidences demonstrate a strong link between sphingosine-1-phosphate (S1P) and both normal physiology and progression of different diseases, including cancer and inflammation. Indeed, numerous ...