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Downregulation of the sonic hedgehog/gli pathway transcriptional target neogenin-1 is associated with basal cell carcinoma aggressiveness.
(2017)
Basal Cell Carcinoma (BCC) is one of the most diagnosed cancers worldwide. It develops due to an unrestrained Sonic Hedgehog (SHH) signaling activity in basal cells of the skin. Certain subtypes of BCC are more aggressive ...
Immunohistochemical evaluation of Sonic Hedgehog signaling pathway proteins (Shh, Ptch1, Ptch2, Smo, Gli1, Gli2, and Gli3) in sporadic and syndromic odontogenic keratocysts
(2018-03-21)
Aims: The aim of this study was to compare the clinical and demographic features of 62 patients presenting sporadic odontogenic keratocysts (OKCs) or OKCs associated with nevoid basal cell carcinoma syndrome (NBCCS). In ...
Heterotrimeric Gi Proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration
(American Society For Biochemistry And Molecular Biology, 2011-07)
Evidence supporting the functionality of Smoothened (SMO), an essential transducer in most pathways engaged by Hedgehog (Hh), as a Gi-coupled receptor contrasts with the lack of an apparently consistent requirement for Gi ...
Shh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte Differentiation
(Public Library Science, 2015)
Primary Cilia (PC) are a very likely place for signal integration where multiple signaling pathways converge. Two major signaling pathways clearly shown to signal through the PC, Sonic Hedgehog (Shh) and PDGF-Ra, are ...
Irradiated Riboflavin Diminishes the Aggressiveness of Melanoma In Vitro and In Vivo
(Public Library ScienceSan FranciscoEUA, 2013)
Sonic Hedgehog (SHH) pathway in the adult brain : key signaling for astrocyte reactivation and brain repairSeñalización Sonic Hedgehog (SHH) en el cerebro adulto : vía crucial para la reactivación de los astrocitos y la reparación del cerebro
(Universidad de Antioquia, Facultad de Ciencias Exactas y Naturales, Instituto de BiologíaGenética, Regeneración y CáncerMedellín, Colombia, 2018)
Sonic Hedgehog signaling and Gli-1 during embryonic chick myogenesis
(Elsevier, 2019)