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Mostrando ítems 11-20 de 47
The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane
(Federation of American Societies for Experimental Biology, 2021-07)
The sodium/iodide symporter (NIS) expresses at the basolateral plasma membrane of the thyroid follicular cell and mediates iodide accumulation required for normal thyroid hormonogenesis. Loss-of-function NIS variants cause ...
Use of sodium iodide symporter expression in differentiated thyroid carcinomas
(Wiley-blackwellHobokenEUA, 2011)
Posttranscriptional regulation of sodium-iodide symporter mRNA expression in the rat thyroid gland by acute iodide administration
(AMER PHYSIOLOGICAL SOC, 2010)
Serrano-Nascimento C, Calil-Silveira J, Nunes MT. Posttranscriptional regulation of sodium-iodide symporter mRNA expression in the rat thyroid gland by acute iodide administration. Am J Physiol Cell Physiol 298: C893-C899, ...
Iodide handling disorders (NIS, TPO, TG, IYD)
(Elsevier, 2017-03)
Iodide Handling Disorders lead to defects of the biosynthesis of thyroid hormones (thyroid dyshormonogenesis, TD) and thereafter congenital hypothyroidism (CH), the most common endocrine disease characterized by low levels ...
The Acute Inhibitory Effect of Iodide Excess on Sodium/Iodide Symporter Expression and Activity Involves the PI3K/Akt Signaling Pathway
(Endocrine Society, 2014-03)
Iodide (I−) is an irreplaceable constituent of thyroid hormones and an important regulator of thyroid function, because high concentrations of I− down-regulate sodium/iodide symporter (NIS) expression and function. In ...
Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen species
(Endocrine Society, 2015)
Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated ...
New insights about the posttranscriptional mechanisms triggered by iodide excess on sodium/iodide symporter (NIS) expression in PCCl3 cells
(ELSEVIER IRELAND LTDCLARE, 2012)
Iodide excess acutely downregulates NIS mRNA expression, as already demonstrated. PCCl3 cells treated or not with Nal, Nal + NaClO4 or Nal + Methimazole, for 30 min to 24 h, were used to further explore how iodide reduces ...