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Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population
(Archives of Endocrinology and Metabolism, 2021)
Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss
(Wiley VCH Verlag, 2017-11)
SCOPE:The biggest challenge for losing weight is the ability to control the amount of food eaten; the tendency to overeat is called disinhibition. Our aims were to determine whether a) the SLC6A4-promoter variant (5-HTTLPR) ...
Impact of cholesterol on ABC and SLC transporters expression and function and its role in disposition variability to lipid-lowering drugs
(FUTURE MEDICINE LTD, 2009)
This report focuses on the effects of cholesterol on the expression and function of the ATP-binding cassette (ABCB1, ABCG2 and ABCC2) and solute-linked carrier (SLCO1B1 and SLCO2B1) drug transporters with a particular focus ...
Haplotypes from the SLC45A2 gene are associated with the presence of freckles and eye, hair and skin pigmentation in Brazil
(2017-03-01)
The Solute Carrier Family 45, Member 2 (SLC45A2) gene encodes the Membrane-Associated Transporter Protein (MATP), which mediates melanin synthesis by tyrosinase trafficking and proton transportation to melanosomes. At least ...
Novel pathogenic mechanism suggested by ex vivo analysis of MCT8 (SLC16A2) mutations
(2009)
Monocarboxylate transporter 8 (MCT8; approved symbol SLC16A2) facilitates cellular uptake and efflux of 3,3′,5-triiodothyronine (T3). Mutations in MCT8 are associated with severe psychomotor retardation, high serum T3 and ...
Drug Transporters
(Springer Nature Switzerland AG, 2018)
Membrane transporters perform a central function in many essential body functions, including traffic and compartmentalization of physiologic compounds, absorption of physiologic compounds (and, occasionally, structurally ...
Association of the SLC6A4 gene 5HTTLPR polymorphism and ADHD with epilepsy, gestational diabetes, and parental substance abuse in Mexican mestizo children
(Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, 2019)