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How C-terminal carboxyamidation alters the biological activity of peptides from the venom of the eumenine solitary wasp
(Amer Chemical Soc, 2004-05-18)
Inflammatory peptides display different types of post-transcriptional modifications, such as C-terminal amidation, that alter their biological activity. Here we describe the structural and molecular dynamics features of ...
Distinct conformational states of the Alzheimer β-amyloid peptide can be detected by high-pressure NMR spectroscopy
(Wiley-VCH VerlagWeinheim, 2013-08)
Folding under pressure: High-pressure NMR spectroscopy detects three different conformational states of the Aβ-peptide in solution: a compactly folded state 1, a partially folded state 2′, and a random-coil like state 2′′ ...
A minor beta-structured conformation is the active state of a fusion peptide of vesicular stomatitis virus glycoprotein
(Wiley-Blackwell, 2008-04-01)
Entry of enveloped animal viruses into their host cells always depends on a step of membrane fusion triggered by conformational changes in viral envelope glycoproteins. Vesicular stomatitis virus (VSV) infection is mediated ...
Molecular and Electronic Structure of the Peptide Subunit of Geobacter sulfurreducens Conductive Phi from First Principles
(AMER CHEMICAL SOCWASHINGTON, 2012)
The respiration of metal oxides by the bacterium Geobacter sulfurreducens requires the assembly of a small peptide (the GS pilin) into conductive filaments termed pili. We gained insights into the contribution of the GS ...
Interaction of a pH-responsive designed nanostructured peptide with a model lipid membrane
(2016-08-01)
Studying molecular interactions of soft biomolecular materials is a key step to the development of novel functional nanostructures with potential application in nanobiotechnology and nanomedicine. In current work we aimed ...
Biological and structural characteristics of the binding peptides from the sporozoite proteins essential for cell traversal (SPECT)-1 and -2
The sporozoite microneme proteins essential for cell traversal, SPECT-1 and SPECT-2, are considered attractive pre-erythrocytic immune targets due to the key role they play in crossing of the malaria parasite across the ...
Disruption of Saccharomyces cerevisiae by Plantaricin 149 and investigation of its mechanism of action with biomembrane model systems
(ELSEVIER SCIENCE BV, 2009)
The action of a synthetic antimicrobial peptide analog of Plantaricin 149 (Pln149a) against Saccharomyces cerevisiae and its interaction with biomembrane model systems were investigated. Pln149a was shown to inhibit S. ...
A solid-state NMR study of the structure and dynamics of the myristoylated N-terminus of the guanylate cyclase-activating protein-2
(Elsevier ScienceAmsterdam, 2010-02)
Guanylate cyclase-activating protein-2 (GCAP-2) is a retinal Ca2+ sensor protein. It plays a central role in shaping the photoreceptor light response and in light adaptation through the Ca2+-dependent regulation of the ...
Studies of plasmodium falciparum rhoptry-associated membrane antigen (RAMA) protein peptides specifically binding to human RBC
Plasmodium falciparum rhoptry-associated membrane antigen (RAMA) peptides used in normal red blood cell (RBC) binding assays revealed that peptides 33426 (79NINILSSVHRKGRILYDSF97) and 33460 (777HKKREKSISPHSYQKVSTKVQ797) ...