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Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth
(Society for Neuroscience, 2017)
Neurons communicate with each other through their axons and dendrites. However, a full characterization of the molecular mechanisms
involved in axon and dendrite formation is still incomplete. Neurite outgrowth requires ...
The Recycling Endosome in Nerve Cell Development: One Rab to Rule Them All?
(Frontiers Media S.A., 2020-12)
Endocytic recycling is an intracellular process that returns internalized molecules back to the plasma membrane and plays crucial roles not only in the reuse of receptor molecules but also in the remodeling of the different ...
Endocytic Rabs Are Recruited to the Trypanosoma cruzi Parasitophorous Vacuole and Contribute to the Process of Infection in Non-professional Phagocytic Cells
(Frontiers Media S.A., 2020-10)
Trypanosoma cruzi is the parasite causative of Chagas disease, a highly disseminated illness endemic in Latin-American countries. T. cruzi has a complex life cycle that involves mammalian hosts and insect vectors both of ...
Alteraciones en el reclutamiento y activación de proteínas Rab durante la infección micobacterianaAlterations in recruitment and activation of Rab proteins during mycobacterial infection
(Instituto Nacional de SaludGrupo de Inmunología Celular e InmunogenéticaBogotá, Colombia, 2023)
GTP-bound Rab3A exhibits consecutive positive and negative roles during human sperm dense-core granule exocytosis
(Oxford University Press, 2014-08)
Exocytosis of mammalian sperm dense-core secretory granule relies on the same fusion molecules as all other secretory cells; one such molecule is the small GTPase Rab3A. Here, we report an in-depth biochemical characterization ...
Alteraciones en el reclutamiento y activación de proteínas Rab en la infección micobacteriana de fagocitos mononucleares
(Instituto Nacional de SaludGrupo de Inmunología Celular e InmunogenéticaBogotá, Colombia, 2023)
Predominant Rab-GTPase amplicons contributing to oral squamous cell carcinoma progression to metastasis
(Oncotarget, 2015-09-08)
Metastatic oral squamous cell carcinoma (OSCC) is frequently associated with recurrent gene abnormalities at specific chromosomal loci. Here, we utilized array comparative genomic hybridization and genome-wide screening ...
A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion
(Landes Bioscience, 2014)
© Jorge Díaz, Pablo endoza, Patricio Silva, Andrew FG Quest, and Vicente A Torres. The small GTPase Rab5 has been frequently studied in the context of intracellular trafficking, but evidence obtained more recently has ...
Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation
(Elsevier, 2015)
The early endosomal protein Rab5 is highly expressed in tumor samples, although a causal relationship between Rab5 expression and cell transformation has not been established. Here, we report the functional effects of ...
Rab35 functions in axon elongation are regulated by P53-related protein kinase in a mechanism that involves Rab35 protein degradation and the microtubule-associated protein 1B
(Society for Neuroscience, 2016)
© 2016 the authors. Rab35 is a key protein for cargo loading in the recycling endosome. In neuronal immortalized cells, Rab35 promotes neurite differentiation. Here we describe that Rab35 favors axon elongation in rat ...