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Genomic Promoter Occupancy of Runt-related Transcription Factor RUNX2 in Osteosarcoma Cells Identifies Genes Involved in Cell Adhesion and Motility
(2012-02-10)
Runt-related transcription factors (RUNX1, RUNX2, and RUNX3) are key lineage-specific regulators of progenitor cell growth and differentiation but also function pathologically as cancer genes that contribute to tumorigenesis. ...
RUNX2 promueve la angiogénesis y la expresión de genes blanco con función pro-angiogénica en osteosarcoma
(Universidad de Chile, 2014)
Runx2 es un factor transcripcional, regulador maestro del desarrollo y de la
diferenciación osteoblástica. Regula positiva o negativamente la expresión de
diversos genes que participan en la proliferación de precursores ...
Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts
(Wiley-Liss Inc., 2018)
© 2018 Wiley Periodicals, Inc. Expression of Runx2/p57 is a hallmark of the osteoblast-lineage identity. Although several regulators that control the expression of Runx2/p57 during osteoblast-lineage commitment have been ...
RUNX2 overexpression generates endocrine resistance in human luminal breast cancer xenografts
(Fundación Revista Medicina, 2021)
T47D and IBH6 cells that overexpress RUNX2 show high levels of FGFR2 and FGF2, supporting the hypothesis that FGF2 increases RUNX2 and, in turn, RUNX2 increases FGF2, maintaining a positive loop. However, in these models ...
Positional differences of axon growth rates between sensory neurons encoded by runx3
(Nature Publishing Group, 2012-09)
The formation of functional connectivity in the nervous system is governed by axon guidance that instructs nerve growth and branching during development, implying a similarity between neuronal subtypes in terms of nerve ...
Nuclear staining of fgfr-2/stat-5 and runx-2 in mucinous breast cancer
(Elsevier, 2016-02)
Mucinous carcinoma (MBC) is a rare subtype of breast cancer characterized by the production of variable amounts of mucin, with a prognosis better than that of non-mucinous carcinomas (NMBC). The aim of this project was to ...
Wnt/β catenin signaling activates expression of the bone-related transcription factor RUNX2 in select human osteosarcoma cell types
(Wiley, 2017)
Osteosarcoma is the most common malignant bone tumor in children and adolescents. Metastasis and poor responsiveness to chemotherapy in osteosarcoma correlates with over-expression of the runt-related transcription factor ...
Runx1 deficiency permits granulocyte lineage commitment but impairs subsequent maturation
(Nature Publishing Group, 2013-11)
First-hits in the multi-hit process of leukemogenesis originate in germline or hematopoietic stem cells (HSCs), yet leukemia-initiating cells (LICs) usually have a lineage-committed phenotype. The molecular mechanisms ...
Role of RUNX2 transcription factor in epithelial mesenchymal transition in non-small cell lung cancer lung cancer: Epigenetic control of the RUNX2 P1 promoter
Lung cancer has a high mortality rate in men and women worldwide. Approximately 15% of diagnosed patients with this type of cancer do not exceed the 5-year survival rate. Unfortunately, diagnosis is established in advanced ...