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Mostrando ítems 11-20 de 121
Synaptic control of mRNA translation by reversible assembly of XRN1 bodies
(Company of Biologists, 2015-04)
Repression of mRNA translation is linked to the formation of specific cytosolic foci such as stress granules and processing bodies, which store or degrade mRNAs. In neurons, synaptic activity regulates translation at the ...
Novel Staufen1 ribonucleoproteins prevent formation of stress granules but favour encapsidation of HIV-1 genomic RNA
(Company Of Biologists, 2010-02)
Human immunodeficiency virus type 1 (HIV-1) Gag selects for and mediates genomic RNA (vRNA) encapsidation into progeny virus particles. The host protein, Staufen1 interacts directly with Gag and is found in ribonucleoprotein ...
Cap binding-independent recruitment of eIF4E to cytoplasmic foci
(Elsevier Science, 2012)
Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2
(Nature Publishing Group, 2007)
Regulation of ribosomal RNA genes is a fundamental process that supports the growth of cells and is tightly coupled with cell differentiation. Although rRNA transcriptional control by RNA polymerase I (Pol I) and associated ...
RNA granules: the good, the bad and the ugly
(Elsevier, 2011)
Processing bodies (PBs) and Stress Granules (SGs) are the founding members of a new class of RNA granules, known as mRNA silencing foci, as they harbour transcripts circumstantially excluded from the translationally active ...
The combination of coffee compounds attenuates early fibrosis-associated hepatocarcinogenesis in mice: involvement of miRNA profile modulation
(2020-11-01)
Aberrant microRNA expression implicates on hepatocellular carcinoma (HCC) development. Conversely, coffee consumption reduces by ~40% the risk for fibrosis/cirrhosis and HCC, while decaffeinated coffee does not. It is ...
Novel mRNA-silencing bodies at the synapse: A never-ending story
(Taylor & Francis, 2016-02)
Several cellular responses depend on translational regulation and in most cases, this involves the formation of cytoplasmic granules that contain repressed mRNAs. In neurons, numerous mRNAs travel along dendrites to be ...
The DEAD-box helicase DDX3 substitutes for the cap-binding protein eIF4E to promote compartmentalized translation initiation of the HIV-1 genomic RNA
(Oxford University Press, 2013)
Here, we show a novel molecular mechanism
promoted by the DEAD-box RNA helicase DDX3 for
translation of the HIV-1 genomic RNA. This occurs
through the adenosine triphosphate-dependent formation
of a translation initiation ...
Oxidant generation predominates around calcifying foci and enhances progression of aortic valve calcification
(LIPPINCOTT WILLIAMS & WILKINS, 2008)
Objective - We hypothesized that reactive oxygen species ( ROS) contribute to progression of aortic valve ( AV) calcification/ stenosis. Methods and Results - We investigated ROS production and effects of antioxidants ...