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Advances on metabolism and disposition of Bbnzimidazoles anthelmintic in Fasciola hepatica: its contribution to the phenomenon of anthelmintic resistance
(Springer, 2019)
The fascioliasis is an important zoonotic disease, particularly in underdeveloped countries. In fascioliasis, the anthelmintic control has been done mainly by the use of triclabendazole (TCBZ), which is metabolized into ...
Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina)
(2011-06)
Triclabendazol (TCBZ) es el fármaco más utilizado para el control de la fasciolosis en rumiantes. Es muy eficaz contra los estadios inmaduros y adultos de Fasciola spp. y frecuentes tratamientos dentro del período prepatente ...
Cathepsin L inhibitors with activity against the liver fluke identified from a focus library of quinoxaline 1,4-di-N-Oxide derivatives
(MDPI, 2019)
Infections caused by Fasciola species are widely distributed in cattle and sheep causing significant economic losses, and are emerging as human zoonosis with increasing reports of human cases, especially in children in ...
Drug resistance in parasitic helminths of veterinary importance in Chile: status review and research needsDrug resistance in parasitic helminths of veterinary importance in Chile: status review and research needs
(Faculty of Veterinary Sciences - Universidad Austral de Chile, 2018)
Testing albendazole resistance in Fasciola hepatica
(Springer, 2020)
The egg development test is a useful in vitro tool to detect albendazole (ABZ) resistance in Fasciola hepatica. ABZ is the only flukicidal compound with ovicidal activity. The described test is based on the ABZ capacity ...
A Multienzyme Response is involved in the Phenomenon of Fasciola hepatica Resistance to Triclabendazole
(OMICS, 2015-10)
The trematode Fasciola hepatica is the causative agent of a parasitic zoonosis known as fasciolosis, disease that affects humans and most species of domestic animals. Triclabendazole (TCBZ) is the most widely used ...
Screening the Pathogen Box for Identification of New Chemical Agents with Anti-Fasciola hepatica Activity
(American Society for Microbiology, 2019)
Fascioliasis is an infectious parasitic disease distributed globally and caused by the liver fluke Fasciola hepatica or F. gigantica This neglected tropical disease affects both animals and humans, and it represents a ...
ANTHELMINTHIC RESISTANCE (FASCIOLA HEPATICA) IN SHEEP AGAINST ALBENDAZOLE AND TRICLABENDAZOLE, LA PAZ - BOLIVIADETERMINACIÓN DE RESISTENCIA ANTIHELMÍNTICA (Fasciola hepatica) EN OVINOS FRENTE A ALBENDAZOL Y TRICLABENDAZOL, LA PAZ – BOLIVIA
(Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria, 2009)
Diagnosis of albendazole resistance in fasciola hepatica
(World Association for the Advancement of Veterinary Parasitology, 2019)
The increasing widespread development of drug resistance in the liver fluke Fasciola hepatica has motivated the need for alternative diagnostic tools. The work reported here describes the validation of an egg hatch test ...
Triclabendazole biotransformation and comparative diffusion of the parent drug and its oxidized metabolites into Fasciola hepatica
(Taylor & Francis Ltd, 2008-09)
Triclabendazole (TCBZ) is an halogenated trematodicidal benzimidazole compound extensively used in veterinary medicine. It is active against immature and adult stages of the liver fluke Fasciola hepatica. Free and conjugated ...