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Effects of unilateral decortication on β-adrenergic receptors in the remaining cortex and in the hypothalamus of female rats
(1986-01-01)
Many experiments have been performed to evaluate the physiological role of catecholaminergic mechanisms of gonadotropin release. The purpose of the present study was to determine the concentration of β-adrenoreceptors in ...
Allosterically linked noncompetitive antagonist binding sites in the resting nicotinic acetylcholine receptor ion channel
(Elsevier Science Inc, 2002-07-01)
Previous studies have established the presence of overlapping binding sites for the noncompetitive antagonists (NCAs) amobarbital, tetracaine, and 3-trifluoromethyl-3-(m-[ 125 I]iodophenyl) diazirine ([ 125 I]TID) within ...
Simplified Tetrandrine Congeners as Possible Antihypertensive Agents with a Dual Mechanism of Action
(American Chemical Society and American Society of Pharmacognosy, 2003-02-07)
A series of O- and/or N-substituted derivatives of (()-coclaurine (1a) were synthesized as simplified
structural mimics of the antihypertensive alkaloid tetrandrine (2) and assayed for binding to brain cortical
sites ...
N-SUBSTITUTION AND α1-ADRENERGIC RECEPTOR AFFINITY OF LAUDANOSINE ANALOGUES
(Sociedad Chilena de Química, 2006-09)
Benzyltetrahydroisoquinoline (BTHIQ) molecules are able to adopt widely differing conformations that depend on the presence or absence of N-substituents.
To assess the possible role of BTHIQ conformation on the affinity ...
N-SUBSTITUTION AND a,-ADRENERGIC RECEPTOR AFFlNITV OJi'LAUDANOSINE ANALOGUES
(Sociedad Chilena de Química, 2006)
Benzyltetrahydroisoquinoline (BTHIQ) molecules are able to adopt widely differing conformations that depend on the presence or absence of N-substituents.
To assess the possible role of BTHIQ conformation on the affinity ...
Coumarins and adenosine receptors: New perceptions in structure–affinity relationships
(Blackwell Publishing Ltd, 2018)
The N terminus of the human alpha(1D)-adrenergic receptor prevents cell surface expression
(Amer Soc Pharmacology Experimental Therapeutics, 2004-04-01)
We previously reported that truncation of the N-terminal 79 amino acids of alpha(1D)-adrenoceptors (Delta(1-79)alpha(1D)-ARs) greatly increases binding site density. In this study, we determined whether this effect was ...
The N terminus of the human alpha(1D)-adrenergic receptor prevents cell surface expression
(Amer Soc Pharmacology Experimental Therapeutics, 2004-04-01)
We previously reported that truncation of the N-terminal 79 amino acids of alpha(1D)-adrenoceptors (Delta(1-79)alpha(1D)-ARs) greatly increases binding site density. In this study, we determined whether this effect was ...
In vivo effects of 3-iodocytisine: Pharmacological and genetic analysis of hypothermia and evaluation of chronic treatment on nicotinic binding sites
(Elsevier Ltd., 2009-05-19)
Several cytisine derivatives have been developed in the search for more selective drugs at nicotinic
acetylcholine receptors (nAChR). Binding experiments in transfected cell lines showed that the iodination
of cytisine ...