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Mostrando ítems 11-20 de 474
Alteraciones en el reclutamiento y activación de proteínas Rab en la infección micobacteriana de fagocitos mononucleares
(Instituto Nacional de SaludGrupo de Inmunología Celular e InmunogenéticaBogotá, Colombia, 2023)
Rab35 functions in axon elongation are regulated by P53-related protein kinase in a mechanism that involves Rab35 protein degradation and the microtubule-associated protein 1B
(Society for Neuroscience, 2016)
© 2016 the authors. Rab35 is a key protein for cargo loading in the recycling endosome. In neuronal immortalized cells, Rab35 promotes neurite differentiation. Here we describe that Rab35 favors axon elongation in rat ...
Rab11-Family of Interacting Protein 2 associates with chlamydial inclusions through its Rab-binding domain and promotes bacterial multiplication
(Wiley, 2012-11-01)
Chlamydia trachomatis, an obligate intracellular pathogen, survives within host cells in a special compartment named ‘inclusion’ and takes advantage of host vesicular transport pathways for its growth and replication. Rab ...
A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion
(Landes Bioscience, 2014)
© Jorge Díaz, Pablo endoza, Patricio Silva, Andrew FG Quest, and Vicente A Torres. The small GTPase Rab5 has been frequently studied in the context of intracellular trafficking, but evidence obtained more recently has ...
Cdk5 regulation of the grab-mediated rab8-rab11 cascade in axon outgrowth
(2017)
Neurons communicate with each other through their axons and dendrites. However, a full characterization of the molecular mechanisms involved in axon and dendrite formation is still incomplete. Neurite outgrowth requires ...
Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation
(Elsevier, 2015)
The early endosomal protein Rab5 is highly expressed in tumor samples, although a causal relationship between Rab5 expression and cell transformation has not been established. Here, we report the functional effects of ...
Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis
(Oncotarget, 2016)
Hypoxia, a common condition of the tumor microenvironment, is associated with poor patient prognosis, tumor cell migration, invasion and metastasis. Recent evidence suggests that hypoxia alters endosome dynamics in tumor ...
Small GTpases in acrosomal exocytosis
(Springer, 2015-01)
Regulated exocytosis employs a conserved molecular machinery in all secretory cells. Soluble N -ethylmaleimide-sensitive factor attachment protein receptor (SNARE) and Rab superfamilies are members of this machinery. Rab ...