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Exercise-based rehabilitation delivery models in comorbid chronic pulmonary disease and chronic heart failure
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Fisioterapia - PPGFtCâmpus São CarlosDepartamento de Fisioterapia - DFisio, 2021-10-13)
An inhalable powder formulation based on micro-and nanoparticles containing 5-fluorouracil for the treatment of metastatic melanoma
(2018-02-01)
Melanoma is the most aggressive and lethal type of skin cancer, with a poor prognosis because of the potential for metastatic spread. The aim was to develop innovative powder formulations for the treatment of metastatic ...
Nanoparticle Formulations and Delivery Strategies for Sustained Drug Release in the Lungs
(Elsevier Academic Press Inc, 2020)
Nanotechnology has recently emerged as a promising tool in biomedicine research. An important branch of nanotechnology is drug delivery and drug targeting using a wide range of biomaterials with promising potential ...
Kinetics of skeletal muscle O-2 delivery and utilization at the onset of heavy-intensity exercise in pulmonary arterial hypertension
(Springer, 2011-08-01)
Impaired O-2 delivery relative to O-2 demands at the onset of exercise might influence the response profile of muscle fractional O-2 extraction (congruent to Delta[deoxy-Hb/Mb] by near-infrared spectroscopy) either by ...
Hybrid inhalable microparticles for dual controlled release of levofloxacin and DNase: Physicochemical characterization and in vivo targeted delivery to the lungs
(Royal Society of Chemistry, 2016-03)
Current medical treatments against recurrent pulmonary infections caused by Pseudomonas aeruginosa, such as cystic fibrosis (CF) disorder, involve the administration of inhalable antibiotics. The main challenge is, however, ...
Heart failure impairs muscle blood flow and endurance exercise tolerance in COPD
(Hospital Clinicas, Univ Sao Paulo, 2016)
Heart failure, a prevalent and disabling co-morbidity of COPD, may impair cardiac output and muscle blood flow thereby contributing to exercise intolerance. To investigate the role of impaired central and peripheral ...
Dendrimer Nanocarriers for Transport Modulation Across Models of the Pulmonary Epithelium
(Amer Chemical Soc, 2015-03-01)
The purpose of this study was to determine the effect of PEGylation on the interaction of poly(amidoamine) (PAMAM) dendrimer nanocarriers (DNCs) with in vitro and in vivo models of the pulmonary epithelium. Generation-3 ...
Controlled Drug Delivery via the Lung
(John Wiley & Sons Inc, 2021)
The lungs fulfill the vital function of transporting and exchanging breathing air. The respiratory tract is considered an excellent delivery route for local and noninvasive administration of active ingredients, even when ...