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Astaxanthin Protects Primary Hippocampal Neurons against Noxious Effects of A beta-Oligomers
(2016)
Increased reactive oxygen species (ROS) generation and the ensuing oxidative stress contribute to Alzheimer's disease pathology. We reported previously that amyloid-beta peptide oligomers (A beta Os) produce aberrant Ca2+ ...
Ryanodine receptor-mediated ca2+ release underlies iron-induced mitochondrial fission and stimulates nnitochondrial ca2+ uptake in primary hippocampal neurons
(FRONTIERS RESEARCH FOUNDATION, 2014)
Mounting evidence indicates that iron accumulation impairs brain function. We have reported previously that addition of sub-lethal concentrations of iron to primary hippocampal neurons produces Ca2+ signals and promotes ...
Astaxanthin protects primary hippocampal neurons against noxious effects of A β-oligomers
(Hindawi Limited, 2016)
© 2016 Pedro Lobos et al.Increased reactive oxygen species (ROS) generation and the ensuing oxidative stress contribute to Alzheimer's disease pathology. We reported previously that amyloid-β peptide oligomers (AβOs) produce ...
Morphological neurite changes induced by porcupine inhibition are rescued by Wnt ligands
(2021)
Abstract
Background
Wnt signaling plays key roles in cellular and physiological processes, including cell proliferation, differentiation and migration during development ...
Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitocondrial fission and stimulates mitocondrial Ca2+ uptake inprimary hippocampal neurons
(2014)
Mounting evidence indicates that iron accumulation impairs brain function. We have reported previously that addition of sub-lethal concentrations of iron to primary hippocampal neurons produces Ca2+ signals and promotes ...
In Vivo and In Vitro Neuronal Plasticity Modulation by Epigenetic Regulators
(Springer, 2018-07)
Prenatal stress (PS) induces molecular changes that alter neural connectivity, increasing the risk for neuropsychiatric disorders. Here we analyzed —in the hippocampus of adult rats exposed to PS— the epigenetic signature ...
Inhibition of tau phosphorylating protein kinase cdk5 prevents β-amyloid-induced neuronal death
(1999)
The key target of this study was the tau protein kinase II system (TPK II) involving the catalytic subunit cdk5 and the regulatory component p35. TPK II is one of the tau phosphorylating systems in neuronal cells, thus ...
Protection of rat primary hippocampal cultures from A beta cytotoxicity by pro-inflammatory molecules is mediated by astrocytes
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005)
The brain of Alzheimer's disease patients shows abundant dystrophic neurites in close proximity to fibrillar beta-amyloid (A beta) plaques, and activated glial cells. We evaluated the influence of pro-inflammatory molecules ...