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Regulation of plasma membrane Ca 2 +-ATPase activity by acetylated tubulin: Influence of the lipid environment
(Elsevier Science, 2012-03)
We demonstrated previously that acetylated tubulin inhibits plasma membrane Ca 2 +-ATPase (PMCA) activity in plasma membrane vesicles (PMVs) of rat brain through a reversible interaction. Dissociation of the PMCA/tubulin ...
Regulation of the Plasma Membrane Calcium ATPases by the actin cytoskeleton
(Academic Press Inc Elsevier Science, 2017-11)
Associations between the cortical cytoskeleton and the components of the plasma membrane are no longer considered to be merely of structural and mechanical nature but are nowadays recognized as dynamic interactions that ...
Hyperactivation of the Human Plasma Membrane Ca2+ Pump PMCA h4xb by Mutation of Glu99 to Lys
(American Society for Biochemistry and Molecular Biology, 2014-04)
The transport of calcium to the extracellular space carried out by plasma membrane Ca2+ pumps (PMCAs) is essential for maintaining low Ca2+ concentrations in the cytosol of eukaryotic cells. The activity of PMCAs is ...
Selectivity of plasma membrane calcium ATPase (PMCA)-mediated extrusion of toxic divalent cations in vitro and in cultured cells
(Springer, 2017-07)
In the recent years, the toxicity of certain divalent cations has been associated with the alteration of intracellular Ca2+ homeostasis. Among other mechanisms, these cations may affect the functionality of certain ...
E2P-like states of plasma membrane Ca2+-ATPase characterization of vanadate and fluoride-stabilized phosphoenzyme analogues
(Elsevier Science, 2019-02)
The plasma membrane Ca2+‑ATPase (PMCA) belongs to the family of P-type ATPases, which share the formation of an acid-stable phosphorylated intermediate as part of their reaction cycle. The crystal structure of PMCA is ...
The role of the Ca2+ binding ligand Asn879 in the function of the plasma membrane Ca2+ pump
(Elsevier Science, 2009-12)
Asn879 in the transmembrane segment M6 of the plasma membrane Ca2+ pump (PMCA human isoform 4xb) has been proposed to coordinate Ca2+ at the transport site through its carboxylate. This idea agrees with the fact that this ...
Changes in islet plasma membrane calcium-ATPase activity and isoform expression induced by insulin resistance
(Elsevier Science Inc, 2009-10)
We studied the effect of insulin resistance (IR) induced by administration of a fructose-rich diet (FRD) to normal Wistar rats for 21 days, upon islet plasma membrane calcium ATPases (PMCAs) and insulin secretion. FRD rats ...
Epigallocatechin 3-gallate inhibits the plasma membrane Ca2+-ATPase: effects on calcium homeostasis
(Elsevier, 2021-02)
Flavonoids are natural compounds responsible for the health benefits of green tea. Some of the flavonoids present in green tea are catechins, among which are: epigallocatechin, epicatechin-3-gallate, epicatechin, catechin ...