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Endovascular treatment of intracavernous carotid aneurysm with hyperprolactinaemia
(Edizioni Centauro, 1998-09-01)
A 42-year-old woman presented with headache, galactorrhoea, marked hyperprolactinemia and normal neurologic examination.CT MR and MR-angiography showed an intracavernous carotid artery aneurysm with minimal displacement ...
Lack of oestrogenic inhibition of the nuclear factor-κB pathway in somatolactotroph tumour cells
(Wiley, 2015-09)
Activation of nuclear factor (NF)-κB promotes cell proliferation and inhibits apoptosis. We have previously shown that oestrogens sensitise normal anterior pituitary cells to the apoptotic effect of tumour necrosis factor ...
Expression of neurotensin and its receptors in pituitary adenomas
(WILEY-BLACKWELL, 2008)
The neurotensin (NT) produced in the hypothalamus and in pituitary gonadotrophs and thyrotrophs participates in neuroendocrine regulation. Recently, the involvement of this peptide in normal and neoplastic cell proliferation ...
Endoscopic endonasal approach for pituitary adenomas: results from a multidisciplinary management
(2021)
Abstract
Background
Endoscopic endonasal approach (EEA) has gained increasing acceptance in the world; however, pituitary adenomas require multidisciplinary management for good outcomes. The aim of this study is to report ...
A expressão de fosfodiesterases da família 4A em adenomas hipofisários esporádicos e em adenomas hipofisários com diferentes mutações do gene que codifica a proteína de interação com o receptor Aril hidrocarbono (AIP)
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em NeurociênciasUFMG, 2015-06-29)
Human phosphodiesterases (PDEs) comprise a complex superfamily of enzymes derived from 21 genes separated into 11 PDE gene families (PDEs 1-11), diffused in different tissues and cells, including heart and brain. The ...
Activin-inhibitory action on lactotrophs is decreased lactotroph hyperplasia
(BioScientifica, 2019-12)
Among all the hormone-secreting pituitary tumours, prolactinomas are the mostfrequently found in the clinic. Since dopamine is the primary inhibitor of lactotroph function, dopamine agonists represent the first-line therapy. ...
Dehydroepiandrosterone treatment attenuates oestrogen-induced pituitary hyperplasia
(BioScientifica, 2002)
The physiological importance of and therapeutic interest in dehydroepiandrosterone (DHEA) has been predominantly in relation to its action as an inhibitor of the promotion and progression of several kinds of tumours, ...
In vivo xenoestrogenic actions of cadmium and arsenic in anterior pituitary and uterus
(BioScientifica, 2016-07-01)
Cadmium (Cd) and arsenic (iAs) are toxic metals ubiquitously present in the environment. Both pollutants exert nonmonotonic dose-responses, being mostly cytotoxic at high concentrations but mimicking estrogen (E2) effects ...