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Enhanced phosphatidylinositol 3-kinase (PI3K)/Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress
(American Society For Biochemistry And Molecular Biology, 2013-05)
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key component in synaptic plasticity and neuronal survival. The aim of this work was to investigate the participation of the PI3K/Akt pathway and its outcome ...
Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region
(Public Library of Science, 2020-11)
Three AKT serine/threonine kinase isoforms (AKT1/AKT2/AKT3) mediate proliferation, metabolism, differentiation and anti-apoptotic signals. AKT isoforms are activated downstream of PI3-kinase and also by PI3-kinase independent ...
Estudo da via de sinalização PI3K-Akt E GSK3β em carcinomas epidermoides metastáticos e não metastáticos de cavidade bucal
(Universidade Federal de UberlândiaBRPrograma de Pós-graduação em Biologia Celular e Estrutural AplicadasCiências BiomédicasUFU, 2016)
The Acute Inhibitory Effect of Iodide Excess on Sodium/Iodide Symporter Expression and Activity Involves the PI3K/Akt Signaling Pathway
(Endocrine Society, 2014-03)
Iodide (I−) is an irreplaceable constituent of thyroid hormones and an important regulator of thyroid function, because high concentrations of I− down-regulate sodium/iodide symporter (NIS) expression and function. In ...
Análise da influência dos inibidores farmacológicos das vias celulares de MEK/ERK, JNK e PI3K/AKT no ciclo de replicação do vírus da febre amarela
(Universidade Federal de Minas GeraisUFMG, 2011-02-22)
During the process of co-evolution with their hosts, the viruses acquired the capacity of intercept, mimic and usurp several cellular signaling pathways in a way to generate favorable conditions to the replication and ...
ATP and UTP stimulate bone morphogenetic protein-2,-4 and -5 gene expression and mineralization by rat primary osteoblasts involving PI3K/AKT pathway
(Elsevier Inc, 2013-08)
The modulation of purinergic receptors plays an important role in the regulation of bone formation by the osteoblast. On the other hand, bone morphogenetic proteins (BMPs), members of the transforming growth factor-β ...
ABI3, a component of the WAVE2 complex, is potentially regulated by PI3K/AKT pathway
(Impact Journals, 2018)
LA ACTIVACIÓN DE LA VÍA DE SEÑALIZACIÓN PI3K/AKT POR EL FACTOR DE CRECIMIENTO SIMILAR A LA INSULINA TIPO II ESTIMULA LA EXPRESIÓN DEL mARN DE LA METALOPROTEINASA 9 EN CÉLULAS DE CORIOCARCINOMA
Metalloproteinases 2 and 9 (MMP-2 and MMP-9) and TissueInhibitor-1 ofMMPs (TIMP-1) could contribute to regulate the invasive behaviour of trophoblastic cells, effect which could be mediated by Insulin-like growth factor ...
Modulatory effects of yerba mate (Ilex paraguariensis) on the PI3K-AKT signaling pathway
(Wiley-blackwellHobokenEUA, 2013)