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Retinoic acid promotes apoptosis and differentiation in photoreceptors by activating the p38 MAP kinase pathway
(Association For Research In Vision And Ophthalmology, 2013-04)
Purpose Retinoic acid (RA) has a critical role during development of the retina, controlling cell fate and differentiation. We here investigated RA effects on photoreceptor differentiation and apoptosis and the intracellular ...
Lutein and Zeaxanthin Protect Photoreceptors from Apoptosis Induced by Oxidative Stress: Relation with Docosahexaenoic Acid
(Association for Research in Vision and Ophthalmology, 2007-11)
Purpose: Oxidative stress has been proposed as a major pathogenic factor in age-related macular degeneration (AMD), the leading cause of vision loss among elderly people of western European ancestry. Lutein (LUT) and ...
Effects of docosahexaenoic acid on retinal development: Cellular and molecular aspects
(Springer Heidelberg, 2001-09)
We have recently shown that docosahexaenoic acid (DHA) is necessary for survival and differentiation of rat retinal photoreceptors during development in vitro. In cultures lacking DHA, retinal neurons developed normally ...
Cell cycle regulation in retinal progenitors by glia-derived neurotrophic factor and docosahexaenoic acid
(Association for Research in Vision and Ophthalmology, 2003-05)
PURPOSE. A recent study has shown that glia-derived neurotrophic factor (GDNF) and docosahexaenoic acid (DHA) promote the survival and differentiation of retina photoreceptors. The current study was undertaken to investigate ...
Sphingolipids as emerging mediators in retina degeneration
(Frontiers Media S.A., 2019-06-11)
The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions. Their roles in the retina have gained ...
Recalculating growth and defense strategies under competition: Key roles of photoreceptors and jasmonates
(Oxford University Press, 2019-05)
The growth-defense trade-off in plant biology has gained enormous traction in the last two decades, highlighting the importance of understanding how plants deal with two of the greatest challenges for their survival and ...
Mifepristone, a blocker of glucocorticoid receptors, promotes photoreceptor death
(Association for Research in Vision and Ophthalmology, 2013-01)
PURPOSE: Glucocorticoids are best known by their protective effect on retinal photoreceptor damage. However, they could also be involved in photoreceptor homeostasis under basal, nonstressful conditions. Therefore, we aimed ...
Oxidative stress promotes proliferation and dedifferentiation of retina glial cells in vitro
(Wiley-liss, Div John Wiley & Sons Inc, 2009-03-14)
Oxidative damage is involved in triggering neuronal death in several retinal neurodegenerative diseases. the recent finding of stem cells in the retina suggests that both preventing neuronal death and replacing lost neurons ...
Forged under the Sun: Life and Art of Extremophiles from Andean Lakes
(Wiley Blackwell Publishing, Inc, 2016-01)
High-altitude Andean lakes (HAAL) are a treasure chest for microbiological research in South America. Their indigenous microbial communities are exposed to extremely high UV irradiation and to multiple chemical extremes ...
P2X7 and A2A receptor endogenous activation protects against neuronal death caused by CoCl2-induced photoreceptor toxicity in the zebrafish retina
(Wiley-liss, div John Wiley & Sons Inc., 2020-01)
Injured retinas in mammals do not regenerate and heal with loss of function. The adult retina of zebrafish self-repairs after damage by activating cell-intrinsic mechanisms, which are regulated by extrinsic signal interactions. ...