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Mostrando ítems 11-20 de 31
Immune Checkpoint Blockade via PD-L1 Potentiates More CD28-Based than 4-1BB-Based Anti-Carbonic Anhydrase IX Chimeric Antigen Receptor T Cells
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2023)
BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade
(Nature Publishing Group, 2021-12)
Bromodomain and Extra-Terminal domain (BET) family proteins are epigenetic readers thatplay a critical role in oncogenesis by controlling the expression of oncogenes such as c-Myc.Targeting BET family proteins has recently ...
Interleukin-17-induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer
(Rockefeller University Press, 2020-12)
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with an immunosuppressive microenvironment that is resistant to most therapies. IL17 is involved in pancreatic tumorigenesis, but its role in invasive ...
Targeting TMEM176B enhances antitumor immunity and augments the efficacy of immune checkpoint blockers by unleashing inflammasome activation
(Cell Press, 2019-05)
Although immune checkpoint blockers have yielded significant clinical benefits in patients with different malignancies, the efficacy of these therapies is still limited. Here, we show that disruption of transmembrane protein ...
PD-1/PD-L1 Pathway Modulates Macrophage Susceptibility to Mycobacterium tuberculosis Specific CD8+ T cell Induced DeathPD-1/PD-L1 Pathway Modulates Macrophage Susceptibility to Mycobacterium tuberculosis Specific CD8+ T cell Induced Death
(Nature Publishing GroupNature Publishing Group, 2019-01)
CD8+T cells contribute to tuberculosis (TB) infection control by inducing death of infected macrophages. Mycobacterium tuberculosis (Mtb) infection is associated with increased PD-1/PD-L1 expression and alternative activation ...
Enhanced antitumor immunity via endocrine therapy prevents mammary tumor relapse and increases immune checkpoint blockade sensitivity
(American Association for Cancer Research, 2021-03)
The role of active antitumor immunity in hormone receptor–positive (HR+) breast cancer has been historically underlooked. The aim of this study was to determine the contribution of the immune system to antiprogestin-induced ...
State of the art in anti-cancer mAbs
(BioMed Central, 2017-02)
Following Milstein’s discovery, the monoclonal antibodies (mAbs) became a basic tool for biomedical science. In cancer field, since the first mAb was approved by the FDA a great improvement took place making of them a ...
Immunostimulatory monoclonal antibodies for hepatocellular carcinoma therapy : trends and perspectivesAnticuerpos monoclonales inmunoestimulantes para el tratamiento del hepatocarcinoma. Avances y perspectivas
(Medicina (Buenos Aires), 2017-12)
Hepatocellular carcinoma (HCC) is the second cause of cancer-related death in the world and isthe main cause of death in cirrhotic patients. Unfortunately, the incidence of HCC has grown significantly in the last decade. ...
Simulação quântica computacional de fármacos imuno-oncológicos
(Universidade Federal do Rio Grande do NorteBrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM BIOQUÍMICA E BIOLOGIA MOLECULAR, 2022-06-10)
Much of the recent excitement in the cancer immunotherapy approach has been generated by
the recognition that immune checkpoint proteins, like the receptors PD-1 (Programmed cell
Death-Ligand 1) and CTLA-4 (Cytotoxic ...
Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy
(Taylor & Francis, 2020-01)
Stat3 is constitutively activated in several tumor types and plays an essential role in maintaining their malignant phenotype and immunosupression. To take advantage of the promising antitumor activity of Stat3 targeting, ...