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Mostrando ítems 11-20 de 25
Expression of Protease Activated Receptor-1 in Chronic Periodontitis
(Amer Acad Periodontology, 2015)
Expression of Protease Activated Receptor-1 in Chronic Periodontitis
(Amer Acad Periodontology, 2015)
El sistema de la proteína C activada en el cuadro séptico
(Sociedad de Cirugía de Bogotá, Hospital de San José y Fundación Universitaria de Ciencias de la Salud, 2011-03-01)
The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA.CER) trial: study design and rationale
(MOSBY-ELSEVIER, 2009)
Background The protease-activated receptor 1 (PAR-1), the main platelet receptor for thrombin, represents a novel target for treatment of arterial thrombosis, and SCH 530348 is an orally active, selective, competitive PAR-1 ...
Characterization of proteolytic activities of Giardia lamblia with the ability to cleave His-tagged N-terminal sequences
(Elsevier Science, 2019-01)
Giardia lamblia is one of the most common protozoan infectious agents in the world and is responsible for diarrheal disease and chronic postinfectious illness. During the host-parasite interaction, proteases are important ...
Caracterização estrutural de um condroitim sulfato isolado do camarão Litopenaeus vannamei: atividade antitumoral em modelo de melanoma murino
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM BIOQUÍMICA, 2019-12-12)
Glycosaminoglycans are sulfated polysaccharides capable of interacting with a
wide range of bioactive molecules, which act in important physiological and
pathological processes, including tumor development. Among these ...
Avaliação de compostos polifenólicos da Laguncularia racemosa sobre a atividade enzimática e farmacológica de serino proteases de Crotalus durissus terrificus.
(Universidade Estadual Paulista (Unesp), 2018-02-22)
A giroxina é a principal serino protease encontrada no veneno total de Crotalus durissus terrificus. As serino proteases de veneno de serpentes são proteínas que apresentam uma grande similaridade estrutural com a trombina ...
Vorapaxar in the Secondary Prevention of Atherothrombotic Events
(MASSACHUSETTS MEDICAL SOCWALTHAM, 2012)
BACKGROUND Thrombin potently activates platelets through the protease-activated receptor PAR-1. Vorapaxar is a novel antiplatelet agent that selectively inhibits the cellular actions of thrombin through antagonism of PAR-1. ...
Thrombin-Receptor Antagonist Vorapaxar in Acute Coronary Syndromes
(MASSACHUSETTS MEDICAL SOCWALTHAM, 2012)
BACKGROUND Vorapaxar is a new oral protease-activated receptor 1 (PAR-1) antagonist that inhibits thrombin-induced platelet activation. METHODS In this multinational, double-blind, randomized trial, we compared vorapaxar ...
Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option?
(BioMed Central, 2014-11)
Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte ...