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Inner hair cell and neuron degeneration contribute to hearing loss in a DFNA2-like mouse model
(Wiley, 2019)
DFNA2 is a progressive deafness caused by mutations in thevoltage-activated potassium channel KCNQ4. Hearing loss developswith age from a mild increase in hearing threshold to profounddeafness. The first phase starts around ...
Auditory Neuropathy: Clinical Evaluation And Diagnostic Approach
(Ordem MedicosLisbon, 2016)
A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells
(Society for Neuroscience, 2004-12)
Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize ...
Could cell membranes produce acoustic streaming? Making the case for synechococcus self-propulsion
(Pergamon-Elsevier Science Ltd, 2011-04)
Sir James Lighthill proposed in 1992 that acoustic streaming (AS) within the mammalian cochlea could play a role in the transmission of acoustic signals to the auditory sensory cells. Microelectromechanical devices for ...
Short-term plasticity and modulation of synaptic transmission at mammalian inhibitory cholinergic olivocochlear synapses
(Frontiers, 2014-12-02)
The organ of Corti, the mammalian sensory epithelium of the inner ear, has two types of mechanoreceptor cells, inner hair cells (IHCs) and outer hair cells (OHCs). In this sensory epithelium, vibrations produced by sound ...
Cochlear hair cells: The sound-sensing machines
(Elsevier, 2015-08-31)
The sensory epithelium of the mammalian inner ear contains two types of mechanosensory cells:inner (IHC) and outer hair cells (OHC). They both transduce mechanical force generated by soundwaves into electrical signals. In ...
Persistência do efeito otoprotetor: qual a duração da otoproteção à amicacina?
(ASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIALSAO PAULO, 2012)
Há comprovação de que o fenômeno de resistência ocorre quando a dose não lesiva da amicacina protege as células ciliadas contra a ototoxicidade da própria amicacina. OBJETIVO: O objetivo deste trabalho é verificar se o ...
SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells
(Academic Press Inc Elsevier Science, 2009-01)
Cochlear hair cells use SK2 currents to shape responses to cholinergic efferent feedback from the brain. Using SK2-/- mice, we demonstrate that, in addition to their previously defined role in modulating hair cell membrane ...
Acoustic streaming, the 'small invention' of cyanobacteria?
(Libreria Cientifica Medinaceli, 2010-12)
Micro-engineering pumping devices without mechanical parts appeared 'way back' in the early 1990's. The working principle is acoustic streaming. Has Nature 'rediscovered' this invention 2.7 Gyr ago? Strands of marine ...