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Is ozone pre-conditioning effect linked to Nrf2/EpRE activation pathway in vivo? A preliminary result
(Elsevier, 2014)
The present preliminary study has been focused on verifying whether ozone preconditioning may be linked to Nrf2/EpRE (nuclear factor erythroid 2/electrophile-responsive element) activation pathway in vivo. Healthy volunteers ...
Molecular mechanisms of gastrointestinal protection by quercetin against indomethacin-induced damage: Role of NF-κB and Nrf2
(Elsevier Inc., 2016)
© 2015 Elsevier Inc.The aim of this study was to determine the gastrointestinal protection by quercetin against indomethacin-induced oxidative stress and inflammation, with specific interest in studying the underlying ...
Electronegative LDL induction of apoptosis in macrophages: Involvement of Nrf2
(ELSEVIER SCIENCE BV, 2010)
The aim of this study was to determine the apoptotic pathways and mechanisms involved in electronegative LDL [LDL(-)]-induced apoptosis in RAW 264.7 macrophages and the role of Nrf2 in this process. Incubation of RAW 264 ...
Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells
(Wiley Blackwell Publishing, Inc, 2018-10)
Mounting evidence implicates chronic oxidative stress as a critical driver of the aging process. Down syndrome (DS) is characterized by a complex phenotype, including early senescence. DS cells display increased levels of ...
Direct and indirect effect of air particles exposure induce Nrf2-dependent cardiomyocyte cellular Response In Vitro
(Humana Press, 2019-05)
Air particulate matter has been associated with adverse effects in the cardiorespiratory system leading to cytotoxic and pro-inflammatory effects. Particulate matter-associated cardiac effects may be direct or indirect. ...
Nrf2 activation in the liver of rats subjected to a preconditioning sub-chronic iron protocol
(THE ROYAL SOCIETY OF CHEMISTRY, 2014)
Thyroid Hormone Administration Induces Rat Liver Nrf2 Activation: Suppression by N-Acetylcysteine Pretreatment
(MARY ANN LIEBERT, INC, 2011)
Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries
(2020-12-01)
Glioblastoma is a severe type of brain tumor with a poor prognosis and few therapy options. Temozolomide (TMZ) is one of these options, however, with limited success, and failure is mainly due to tumor resistance. In this ...