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Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation
(Facultad de Medicina y Ciencia, 2019)
Background Neuroinflammation constitutes a pathogenic process leading to neurodegeneration in several disorders, including Alzheimer's disease, Parkinson's disease (PD) and sepsis. Despite microglial cells being the central ...
Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation
(BioMed Central, 2019)
BACKGROUND:
Neuroinflammation constitutes a pathogenic process leading to neurodegeneration in several disorders, including Alzheimer's disease, Parkinson's disease (PD) and sepsis. Despite microglial cells being the central ...
Neuroinflammation in Huntington’s Disease: A Starring Role for Astro-cyte and Microglia
(Bentham Science Publishers, 2021-11-26)
Huntington’s disease (HD) is a neurodegenerative genetic disorder caused by a CAG repeat expansion in the huntingtin gene. HD causes motor, cognitive, and behavioral dysfunction. Since no existing treatment affects the ...
Neuroinflammation : A therapeutic target of cotinine for the treatment of psychiatric disorders?
(2016-03-01)
Neuroinflammation is a common characteristic of several mental health conditions such as major depression, bipolar disorder, post-traumatic stress disorder (PTSD) and schizophrenia (SCHZ). Inflammatory processes trigger ...
Relationship between Hypoxic and Immune Pathways Activation in the Progression of Neuroinflammation : Role of HIF-1α and Th17 Cells
(2023-02)
Neuroinflammation is a common event in degenerative diseases of the central and peripheral nervous system, triggered by alterations in the immune system or inflammatory cascade. The pathophysiology of these disorders is ...
Suprachiasmatic Nucleus and Subordinate Brain Oscillators: Clock Gene Desynchronization by Neuroinflammation
(2018-03-01)
Objective: The clock genes Period (per) 1 and 2 are essential components in the generation and adjustment of biological circadian rhythms by the suprachiasmatic nucleus (SCN). Both genes are also rhythmically present in ...
The Unfolded protein response in immune cells as an emerging regulator of neuroinflammation
(Frontiers Media, 2021)
Immune surveillance is an essential process that safeguards the homeostasis of a healthy brain. Among the increasing diversity of immune cells present in the central nervous system (CNS), microglia have emerged as a prominent ...