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The alpha 7, alpha 4 beta 2 and alpha 3 beta 4 Nicotinic Acetylcholine Receptors: Characteristics, Role in Pathogenic Processes and Bioactive Compounds
(Brazilian Chemical Soc, 2016-01-01)
Neuronal nicotinic acetylcholine receptors (nAChRs) are potential targets for the treatement of several central nervous system disorders, including Alzheimer's disease, Parkinson's disease and schzophrenia. On this review ...
Acute Lung Injury in Cholinergic-Deficient Mice Supports Anti-Inflammatory Role of α7 Nicotinic Acetylcholine Receptor
(Nicola Scichilone, 2021-07)
Abstract: (1) Background: The lung cholinergic pathway is important for controlling pulmonary inflammation in acute lung injury, a condition that is characterized by a sudden onset and intense inflammation. This study ...
Targeting the nicotinic acetylcholine receptors (nAChRs) in astrocytes as a potential therapeutic target in Parkinson’s disease
(Bentham Science Publishers, 2016)
Sensitization-dependent nicotine place preference in the adult zebrafish
(Pergamon-Elsevier Science Ltd, 2019-06)
Sensitization of motor activity is a behavioural test to evaluate the effects of psychostimulants. Conditioned place preference (CPP) is an associative learning procedure to examine the rewarding properties of drugs. We ...
Acute behavioural responses to nicotine and nicotine withdrawal syndrome are modified in GABAB1 knockout mice
(Pergamon-Elsevier Science Ltd, 2012-10)
Nicotine is the main active component of tobacco, and has both acute and chronic pharmacological effects that can contribute to its abuse potential in humans. The aim of the present study was to evaluate a possible role ...
Preservation of Alpha-3 Neuronal Nicotinic Acetylcholine Receptor Expression in Sympathetic Ganglia After Brain Death
(HUMANA PRESS INCTOTOWA, 2012-04)
The goal of this study was to evaluate if the immunohistochemical expression of alpha-3 neuronal nicotinic acetylcholine receptor subunit in sympathetic ganglia remains stable after brain death, determining the possible ...
Alpha7 Nicotinic Acetylcholine Receptor Expression and Activity During Neuronal Differentiation of PC12 Pheochromocytoma Cells
(HUMANA PRESS INC, 2010)
Nicotinic acetylcholine receptors (nAChR) exert pivotal roles in synaptic transmission, neuroprotection and differentiation. Particularly, homomeric alpha 7 receptors participate in neurite outgrowth, presynaptic control ...
Pre-exposure to nicotine with nocturnal abstinence induces epigenetic changes that potentiate nicotine preference
(Humana Press, 2019-12)
Prior exposure to drugs of abuse may facilitate addiction. It has been described that pre-exposure to nicotine can increase or, contrarily, prevent conditioned place preference (CPP). Here, we evaluated the effect of ...