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Targeting the nicotinic acetylcholine receptors (nAChRs) in astrocytes as a potential therapeutic target in Parkinson’s disease
(Bentham Science Publishers, 2016)
Neurotransmitter GABA Activates Muscle but not a7 Nicotinic Receptors
(American Society For Pharmacology And Experimental Therapeutics, 2015-03)
Cys-loop receptors are neurotransmitter-activated ion channels involved in synaptic and extrasynaptic transmission in the brain and are also present in non-neuronal cells. As GABAA and nicotinic receptors (nAChR) belong ...
Molecular Determinants of Pyrantel Selectivity in Nicotinic Receptors
(American Society for Pharmacology and Experimental Therapeutics, 2006-12)
Nicotinic receptors (AChRs) play key roles in synaptic transmission throughout the nervous system. AChRs mediate neuromuscular transmission in nematodes and they are targets for antiparasitic drugs. The anthelmintic agents ...
Alpha7 Nicotinic Acetylcholine Receptor Expression and Activity During Neuronal Differentiation of PC12 Pheochromocytoma Cells
(HUMANA PRESS INC, 2010)
Nicotinic acetylcholine receptors (nAChR) exert pivotal roles in synaptic transmission, neuroprotection and differentiation. Particularly, homomeric alpha 7 receptors participate in neurite outgrowth, presynaptic control ...
The alpha 7, alpha 4 beta 2 and alpha 3 beta 4 Nicotinic Acetylcholine Receptors: Characteristics, Role in Pathogenic Processes and Bioactive Compounds
(Brazilian Chemical Soc, 2016-01-01)
Neuronal nicotinic acetylcholine receptors (nAChRs) are potential targets for the treatement of several central nervous system disorders, including Alzheimer's disease, Parkinson's disease and schzophrenia. On this review ...
Effects of acetylcholine and cholinergic antagonists on the activity of nucleus of the solitary tract neurons
(Elsevier B.V., 2017-03-15)
Previously we have demonstrated that microinjection of acetylcholine (ACh) into the intermediate nucleus of the solitary tract (iNTS) induced sympatho-inhibition combined with a decrease in the phrenic nerve activity (PNA), ...
Activation of Caenorhabditis elegans Levamisole-Sensitive and Mammalian Nicotinic Receptors by the Antiparasitic Bephenium
(American Society for Pharmacology and Experimental Therapeutics, 2018-11)
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels involved in neuromuscular transmission. In nematodes, muscle nAChRs are targets of antiparasitic drugs. Bephenium is an anthelmintic compound whose ...
The nicotinic acetylcholine receptor as a molecular machine for neuromuscular transmission
(Elsevier, 2018-08)
The nicotinic acetylcholine receptor (nAChR) has crucial functions at the neuromuscular junction (NMJ). It belongs to the superfamily of pentameric ligand-gated ion channels and has become the stereotype for probing ...
Neonicotinic analogues: Selective antagonists for a4b2 nicotinic acetylcholine receptors
(Elsevier, 2013)
Nicotine is an agonist of nicotinic acetylcholine receptors (nAChRs)that has been extensively used as a
template for the synthesis of a4b2-prefer ring nAChRs.Here,we used the N-methyl-pyrrolidine moiety
of nicotine to ...
Corticosterone affects the differentiation of a neuronal cerebral cortex-derived cell line through modulation of the nicotinic acetylcholine receptor
(Elsevier, 2014-08-22)
Chronic exposure to stress hormones has an impact on brain structures relevant to cognition. Nicotinic acetylcholine receptors (AChRs) are involved in numerous cognitive processes including learning and memory formation. ...