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Insulin-like growth factor-I is a potential trophic factor for amacrine cells
(Wiley Blackwell Publishing, Inc, 2001-02)
In this study we show that insulin-like growth factor (IGF)-I selectively promotes survival and differentiation of amacrine neurons. In cultures lacking this factor, an initial degeneration pathway, selectively affecting ...
A new experimental protocol for preferential differentiation of mouse embryonic stem cells into insulin-producing cells
(Cognizant Communication Corp, 2008-12)
Mouse embiyonic stem (ES) cells have the potential to differentiate into insulin-producing cells, but efficient protocols for in vitro differentiation have not been established. Here we have developed a new optimized ...
Wingless-type family member 3A triggers neuronal polarization via cross-activation of the insulin-like growth factor-1 receptor pathway
(Frontiers, 2013-10)
Initial axonal elongation is essential for neuronal polarization and requires polarized activation of IGF-1 receptors (IGF-1r) and the phosphatidylinositol 3 kinase (PI3k) pathway. Wingless-type family growth factors (Wnts) ...
Palmitic acid reduces the autophagic flux and insulin sensitivity through the activation of the free fatty acid receptor 1 (FFAR1) in the hypothalamic neuronal cell line N43/5
(Frontiers Media S.A., 2019)
Copyright © 2019 Hernández-Cáceres, Toledo-Valenzuela, Díaz-Castro, Ávalos, Burgos, Narro, Peña-Oyarzun, Espinoza-Caicedo, Cifuentes-Araneda, Navarro-Aguad, Riquelme, Troncoso, Criollo and Morselli. This is an open-access ...
Palmitic and Stearic Acids Inhibit Chaperone-Mediated Autophagy (CMA) in POMC-like Neurons In Vitro
(2022)
The intake of food with high levels of saturated fatty acids (SatFAs) is associated with
the development of obesity and insulin resistance. SatFAs, such as palmitic (PA) and stearic (SA) acids, have been shown to accumulate ...
An insulin like-peptide, INS-3, bridges neural perception of stressors with intracellular defensive mechanisms in non-neuronal cells of C. elegans
(Sociedad Argentina de Investigación en Neurociencias, 2018)
Multicellular organisms coordinate the systemic response to stress. We have shown that in C. elegans the acute-stress response activates neurons that release tyramine (TA), the invertebrate analog of adrenaline/noradrenaline. ...
Palmitic and stearic acids inhibit chaperone-mediated autophagy (CMA) in POMC-like neurons In vitro
(MDPI, 2022)
The intake of food with high levels of saturated fatty acids (SatFAs) is associated with the development of obesity and insulin resistance. SatFAs, such as palmitic (PA) and stearic (SA) acids, have been shown to accumulate ...