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Influence of apocynin on cardiac remodeling in rats with streptozotocin-induced diabetes mellitus
(2018-01-17)
Background: Increased reactive oxygen species (ROS) generation in diabetes mellitus (DM) is an important mechanism leading to diabetic cardiomyopathy. Apocynin, a drug isolated from the herb Picrorhiza kurroa, is considered ...
Islet NADPH oxidase activity modulates β-cell mass and endocrine function in rats with fructose-induced oxidative stress
(Elsevier Science, 2014-12)
Background: Islet NADPH oxidase activity is modulated by glucose and other insulin secretagogues and it might be part of the regulatory mechanism of insulin secretion. We studied its modulatory role of islet NADPH oxidase ...
Dietary (-)-epicatechin affects NF-kB activation and NADPH-oxidases in the kidney cortex of high fructose-fed rats
(Royal Society of Chemistry, 2019-02)
Inflammation involves the activation of redox-sensitive transcription factors, e.g. nuclear factor kB (NF-kB). Administration of (-)-epicatechin to high fructose-fed rats prevented NF-kB activation, and up-regulation of ...
Dietary (-)-epicatechin affects NF-kappa;B activation and NADPH oxidases in the kidney cortex of high-fructose-fed rats
(Royal Society of Chemistry, 2019-01)
Inflammation involves the activation of redox-sensitive transcription factors, e.g., nuclear factor κB (NF-κB). Administration of (−)-epicatechin to high-fructose-fed rats prevented NF-κB activation and up-regulation of ...
DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis
(American Thoracic Society, 2018)
Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase
(BioMed Central, 2017)
Modulation of rat neutrophil function in vitro by cis- and trans-MUFA
(CAMBRIDGE UNIV PRESS, 2009)
In the present study, the effects of trans-MUFA, elaidic acid (EA; 18 : 1-9t) and vaccenic acid (VA; 18 : 1-11t) on rat neutrophil functions were compared with those of cis-monounsaturated oleic acid (OA) (18 : 1-9c) and ...
Synthesis, antioxidant and anti-inflammatory properties of an apocynin-derived dihydrocoumarin
(2017-01-01)
Background: Coumarin derivatives as dihydrocoumarins have been reported to have multiple biological activities, such as antioxidant and anti-inflammatory properties. Apocynin (APO), which is a substituted-methoxy-catechol, ...
Protein disulfide isomerase overexpression in vascular smooth muscle cells induces spontaneous preemptive NADPH oxidase activation and Nox1 mRNA expression: Effects of nitrosothiol exposure
(ELSEVIER SCIENCE INC, 2009)
Mechanisms regulating NADPH oxidase remain open and include the redox chaperone protein disulfide isomerase (PDI). Here, we further investigated PDI effects on vascular NADPH oxidase. VSMC transfected with wild-type PDI ...