Buscar
Mostrando ítems 11-20 de 565
Muscarinic drugs regulate the PKG-II-dependent phosphorylation of M3 muscarinic acetylcholine receptors at plasma membranes from airway smooth muscle
(Journal of Receptors and Signal Transduction, 2017)
Mice lacking M1 and M3 muscarinic acetylcholine receptors have impaired odor discrimination and learning
(Frontiers Research Foundation, 2017)
Conformational and stereoeletronic investigations of muscarinic agonists of acetylcholine by NMR and theoretical calculations
(Elsevier Science BvAmsterdamHolanda, 2012)
Autoantibodies against muscarinic receptors in breast cancer. Its role in tumor angiogenesis.
(Public Library Science, 2013-02)
The presence of autoantibodies in cancer has become relevant in recent years. We demonstrated that autoantibodies purified from the sera of breast cancer patients activate muscarinic acetylcholine receptors in tumor cells. Immunoglobulin G (IgG) from breast cancer patients in T1N0Mx stage (tumor size¡Ü2 cm, without lymph node metastasis) mimics the action of the muscarinic agonist carbachol stimulating MCF-7 cell proliferation, migration and invasion. Angiogenesis is a central step in tumor progression because it promotes tumor invasion and metastatic spread. Vascular endothelial growth factor-A (VEGF-A) is the main angiogenic mediator, and its levels have been correlated with poor prognosis in cancer. The aim of the present work was to investigate the effect of T1N0Mx-IgG on the expression of VEGF-A, and the in vivo neovascular response triggered by MCF-7 cells, via muscarinic receptor activation. We demonstrated that T1N0Mx-IgG (10<sup><font size="2">−8</font></sup> M) and carbachol (10<sup><font size="2">−9</font></sup> M) increased the constitutive expression of VEGF-A in tumor cells, effect that was reverted by the muscarinic antagonist atropine. We also observed that T1N0Mx-IgG and carbachol enhanced the neovascular response produced by MCF-7 cells in the skin of NUDE mice. The action of IgG or carbachol was reduced in the presence of atropine. In conclusion, T1N0Mx-IgG and carbachol may promote VEGF-A production and neovascularization induced by breast tumor cells via muscarinic receptors activation. These effects may be accelerating breast tumor progression....
The analgesic effect of crotoxin on neuropathic pain is mediated by central muscarinic receptors and 5-lipoxygenase-derived mediators
(Pergamon-Elsevier B.V. Ltd, 2008-12-01)
Crotoxin (CTX). a neurotoxin isolated from the venom of the South American rattlesnake Crotalus durissus terrificus. induces analgesia. In this study, we evaluated the antinociceptive effect of CTX in a model of neuropathic ...
Muscarinic acetylcholine receptor subtypes in the rat seminal vesicle
(Elsevier B.V., 2006-03-09)
The aim of the present study was to identify the muscarinic acetylcholine receptor (mAChR) mRNA subtypes in the rat seminal vesicle. Furthermore, the mAChR subtypes involved in the contraction of the seminal vesicle were ...
Differential activation of nitric oxide synthase through muscarinic acetylcholine receptors in rat salivary glands
(Elsevier, 2000-03)
Muscarinic receptors play an important role in secretory and vasodilator responses in rat salivary glands. Nitric oxide synthase (NOS) appears to be one of the multiple effectors coupled to muscarinic receptors in both ...
Ketamine prevents seizures and reverses changes in muscarinic receptor induced by bicuculline in rats
(Elsevier, 2013-02)
The cholinergic system has been implicated in several experimental epilepsy models. In a previous study bicuculline (BIC), known to antagonize GABA-A postsynaptic receptor subtype, was administered to rats at subconvulsant ...
Central muscarinic receptors signal pilocarpine-induced salivation
(Sage Publications Inc, 2014)
Effects of carbachol on rat Sertoli cell proliferation and muscarinic acetylcholine receptors regulation: an in vitro study
(Elsevier B.V., 2004-08-20)
The aim of the present work was to study the effect of muscarinic agonist on cell proliferation and muscarinic acetylcholine receptors (mAChRs) regulation in rat Sertoli cells. Primary cultures of Sertoli cells were obtained ...