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Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice
(Elsevier, 2014-12)
Chronic use of methamphetamine (METH) leads to long-lasting cognitive dysfunction in humans and in animal models. Modafinil is a wake-promoting compound approved for the treatment of sleeping disorders. It is also prescribed ...
Differential effects of environment-induced changes in body temperature on modafinil's actions against methamphetamine-induced striatal toxicity in mice
(Springer, 2015-01)
Methamphetamine (METH) exposure can produce hyperthermia that might lead to toxicity and death. Modafinil is a wake-promoting compound that is also been prescribed off-label to treat METH dependence. Modafinil has shown ...
Methylphenidate and Modafinil: egalitarian justice and policies of access to pharmacological cognitive enhancement.
The article addresses criteria for access to pharmacological cognitive enhancement technologies, especially modafinil and methylphenidate, to healthy adults. From the perspective of equalitarian justice and taking as point ...
Placebo and modafinil effect on sleepiness in obstructive sleep apnea
(Elsevier B.V., 2008-02-15)
Introduction: Previous studies have evaluated the effect of modafinil on residual excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea syndrome (OSAS) under effective CPAP treatment. Even though those ...
Fatores envolvidos no desenvolvimento e expressão da sensibilização comportamental ao efeito estimulante do modafinil e metanfetamina
(Universidade Federal de São Paulo (UNIFESP), 2010-04-28)
The behavioral sensitization refers to the progressive increase of the stimulatory effect induced by repeated administration of drugs of abuse such as cocaine and amphetamine. Previous studies suggest that the environment ...
Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex
(Pergamon-Elsevier Science Ltd, 2018-03)
Methamphetamine (METH) and modafinil are psychostimulants with different long-term cognitive profiles: METH is addictive and leads to cognitive decline, whereas modafinil has little abuse liability and is a cognitive ...
Effects of cocaine, methamphetamine and modafinil challenge on sleep rebound after paradoxical sleep deprivation in rats
(Associação Brasileira de Divulgação Científica, 2008-01-01)
Sleep loss is both common and critically relevant to our society and might lead to the abuse of psychostimulants such as amphetamines, cocaine and modafinil. Since psychoactive substance abuse often occurs within a scenario ...
HDAC superfamily promoters acetylation is differentially regulated by modafinil and methamphetamine in the mouse medial prefrontal cortex
(Wiley Blackwell Publishing, Inc, 2019-02)
Dysregulation of histone deacetylases (HDAC) has been proposed as a potential contributor to aberrant transcriptional profiles that can lead to changes in cognitive functions. It is known that METH negatively impacts the ...