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Mineralocorticoid receptor activation following acute myocardial stretch
(Sociedad Argentina de Fisiología. Centro de Investigaciones Cardiovasculares. Universidad Nacional de La Plata, 2017-08)
Myocardial stretch induces a two-phase increase in developed force. The first phase occurs immediately, is due to an increase in myofilament Ca2+ responsiveness, and is the expression of the Frank-Starling mechanism. The ...
Molecular mechanism of activation and nuclear translocation of the mineralocorticoid receptor upon binding of pregnanesteroids
(Elsevier Ireland, 2003-12)
The mineralocorticoid receptor (MR) is primarily localized in the cytoplasm of the cell in the absence of ligand. The first step in the genomic-dependent mechanism of action of mineralocorticoids is the binding of steroid ...
El receptor cardíaco de mineralocorticoides: pasado, presente y futuroHeart mineralocorticoid receptor: past, present and future
(Federación Argentina de Cardiología, 2015-05)
Tres ensayos clínicos realizados en el transcurso de los últimos 20 años –RALES, EPHESUS y EMPHASIS-HF- marcaron un nuevo hito en el tratamiento de la insuficiencia cardíaca (IC)1-3. Demostraron que el uso de antagonistas ...
Envolvimento dos receptores centrais angiotensinérgicos e mineralocorticóides no aumento do apetite ao sódio induzido por privação hídrica em ratos com hipertensão renovascular
(Universidade Federal de São CarlosUFSCarPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCFCâmpus São Carlos, 2020-04-27)
Sodium appetite in normotensive rats submitted to water deprivation (WD) for 24 h followed by 2 h with access to water only (partial rehydration–PR) depends on the activation of the renin-angiotensin system (RAS). ...
Molecular basis of mineralocorticoid receptor action in the nervous system
(Bentham Science Publishers, 2013-12)
The most relevant biological action of aldosterone in epithelial tissues is the regulation of sodium reabsorption through binding to the mineralocorticoid receptor (MR). Glucocorticoids also bind with high affinity to MR, ...
Opposing roles of glucocorticoid receptor and mineralocorticoid receptor in trimethyltin-induced cytotoxicity in the mouse hippocampus
(Elsevier Ireland, 2012-03)
The organotin trimethyltin (TMT) is known to cause neuronal degeneration in the murine brain. Earlier studies indicate that TMT-induced neuronal degeneration is enhanced by adrenalectomy and prevented by exogenous ...
Mineralocorticoid Receptor Antagonism Attenuates Cardiac Hypertrophy and Prevents Oxidative Stress in Uremic Rats
(2008)
Chronic renal failure causes left ventricular hypertrophy, but the molecular mechanisms involved remain unknown. We, therefore, investigated whether the mineralocorticoid receptor is implicated in the cardiac hypertrophy ...
Modulation of Immunity and Inflammation by the Mineralocorticoid Receptor and Aldosterone
(2015)
The mineralocorticoid receptor (MR) is a ligand dependent transcription factor. MR has been traditionally associated with the control of water and electrolyte homeostasis in order to keep blood pressure through aldosterone ...