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Mostrando ítems 11-20 de 1807
Contrasting patterns of selection between MHC I and II across populations of Humboldt and Magellanic penguins
(2016)
The evolutionary and adaptive potential of populations or species facing an emerging infectious disease depends on their genetic diversity in genes, such as the major histocompatibility complex (MHC). In birds, MHC class ...
Improved pan-specific prediction of MHC class I peptide binding using a novel receptor clustering data partitioning strategy
(Wiley Blackwell Publishing, Inc, 2016-12)
Pan-specific prediction of receptor–ligand interaction is conventionally done using machine-learning methods that integrates information about both receptor and ligand primary sequences. To achieve optimal performance using ...
Gapped sequence alignment using artificial neural networks: Application to the MHC class I system
(Oxford University Press, 2016-02-15)
Motivation: Many biological processes are guided by receptor interactions with linear ligands of variable length. One such receptor is the MHC class I molecule. The length preferences vary depending on the MHC allele, but ...
Immunoinformatics: Predicting Peptide–MHC Binding
(Annual Review, 2020-07)
Immunoinformatics is a discipline that applies methods of computer science to study and model the immune system. A fundamental question addressed by immunoinformatics is how to understand the rules of antigen presentation ...
Identification of the cognate peptide-MHC target of T cell receptors using molecular modeling and force field scoring
(Pergamon-Elsevier Science Ltd, 2018-02)
Interactions of T cell receptors (TCR) to peptides in complex with MHC (p:MHC) are key features that mediate cellular immune responses. While MHC binding is required for a peptide to be presented to T cells, not all MHC ...
Contrasting patterns of selection between MHC I and II across populations of Humboldt and Magellanic penguins
(John Wiley & Sons Inc, 2016-10)
The evolutionary and adaptive potential of populations or species facing an emerginginfectious disease depends on their genetic diversity in genes, such as the major histocompatibilitycomplex (MHC). In birds, MHC class I ...
Surviving despite reduce MHC variation: selection patterns and genetic variation of the endangered Huillín (Lontra provocax)
(Springer Science and Business Media Deutschland GmbH, 2021)
© 2021, Mammal Research Institute, Polish Academy of Sciences, Bialowieza, Poland.The major histocompatibility complex (MHC) is a highly polymorphic gene group that mediates the vertebrate immune response through antigen ...
MHC class I and II expression in juvenile dermatomyositis skeletal muscle
(CLINICAL & EXPER RHEUMATOLOGY, 2009)
Objective To assess MHC I and II expressions in muscle fibres of juvenile dermatomyositis (JDM) and compare with the expression in polymyositis (PM), dermatomyositis (DM) and dystrophy. Patients and methods Forty-eight JDM ...
NNAlign-MA; MHC peptidome deconvolution for accurate MHC binding motif characterization and improved t-cell epitope predictions
(American Society for Biochemistry and Molecular Biology, 2019-10)
The set of peptides presented on a cell´s surface by MHC molecules is known as the immunopeptidome. Current mass spectrometry technologies allow for identification of large peptidomes, and studies have proven these data ...
Análises Filogenéticas da Região MHC em Primatas: Evolução do Gene MHC-G
(Florianópolis, SC., 2017)