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The effect of flake orientation on the permeability of barrier membranes: numerical simulations and predictive models
(Elsevier Science, 2016-04-26)
This work presents results of numerical simulations along with the development of simple analytical forms aimed at predicting diffusivity in barrier membranes with randomly dispersed flakes. Simulations are performed using ...
Insights into peptide-membrane interactions of newly synthesized, nitroxide-containing analogs of the peptaibiotic trichogin GA IV using EPR
(John Wiley & Sons Inc, 2017-01)
Trichogin GA IV is a short-length (10-amino acid long), mostly hydrophobic, peptaibiotic with an N-terminal fatty acyl chain and a C-terminal 1,2-amino alcohol. A cardinal role of the terminal moieties in the cytotoxic ...
Functional and Topological Studies with Trp-Containing Analogs of the Peptide StII(1-30) Derived From the N-Terminus of the Pore Forming Toxin Sticholysin II: Contribution to Understand its Orientation in Membrane
(Wiley-Blackwell, 2013-07-01)
Sticholysin II (St II) is the most potent cytolysin produced by the sea anemone Stichodactyla helianthus, exerting hemolytic activity via pore formation in membranes. The toxin's N-terminus contains an amphipathic alpha-helix ...
MHC I presentation of Toxoplasma gondii immunodominant antigen does not require Sec22b and is regulated by antigen orientation at the vacuole membrane
(Wiley VCH Verlag, 2017-07)
The intracellular Toxoplasma gondii parasite replicates within a parasitophorous vacuole (PV). T. gondii secretes proteins that remain soluble in the PV space, are inserted into PV membranes or are exported beyond the PV ...
Trichogin GA IV Alignment and Oligomerization in Phospholipid Bilayers
(Wiley VCH Verlag, 2019-05)
Trichogin GA IV is a short peptaibol with antimicrobial activity. This uncharged, but amphipathic, sequence is aligned at the membrane interface and undergoes a transition to an aggregated state that inserts more deeply ...
Dynamics and orientation of parathion dissolved in a discotic nematic lyomesophase
(CSIRO Publishing, 2008)
Parathion, an organophosphorous pesticide, presents serious hazards to the environment and health. It inhibits acetylcholinesterase, an enzyme incorporated in the cell membrane. A study on the behaviour of parathion in a ...
Similarities and differences of serotonin and its precursors in their interactions with model membranes studied by molecular dynamics simulation
(Elsevier Science, 2013-06)
In this work, we report a Molecular Dynamics (MD) simulations study of relevant biological molecules as serotonin (neutral and protonated) and its precursors, tryptophan and 5-hydroxy-tryptophan, in a fully hydrated bilayer ...