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Galectin-8 Induces Apoptosis in Jurkat T Cells by Phosphatidic Acid-mediated ERK1/2 Activation Supported by Protein Kinase A Down-regulation
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2009)
Galectins have been implicated in T cell homeostasis playing complementary pro-apoptotic roles. Here we show that galectin-8 (Gal-8) is a potent pro-apoptotic agent in Jurkat T cells inducing a complex phospholipase ...
Proliferative signaling initiated in ACTH receptors
(Assoc Bras Divulg Cientifica, 2000-10-01)
This article reviews recent results of studies aiming to elucidate modes of integrating signals initiated in ACTH receptors and FGF2 receptors, within the network system of signal transduction found in Y1 adrenocortical ...
Phosphoproteome Reveals an Atlas of Protein Signaling Networks During Osteoblast Adhesion
(Wiley-lissHobokenEUA, 2010)
Signaling cascades transmit information downstream and upstream but unlikely simultaneously
(BioMed Central, 2016-08)
Background: Signal transduction is the process through which cells communicate with the external environment, interpret stimuli and respond to them. This mechanism is controlled by signaling cascades, which play the role ...
MAPK7 Gene Controls Proliferation, Migration and Cell Invasion in Osteosarcoma
(Wiley-Blackwell, 2016)
Osteosarcomas (OS) are the most common malignant bone tumors, and the identification of useful tumor biomarkers and target proteins is required to predict the clinical outcome of patients and therapeutic response as well ...
Single-cell profiling screen identifies microtubule-dependent reduction of variability in signaling
(Nature Publishing Group, 2018-04)
Populations of isogenic cells often respond coherently to signals, despite differences in protein abundance and cell state. Previously, we uncovered processes in the Saccharomyces cerevisiae pheromone response system (PRS) ...
Galectin-8 binds specific beta 1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells
(ELSEVIER INC, 2006)
Integrin-mediated encounters of T cells with extracellular cues lead these cells to adhere to a variety of substrates and acquire a spread phenotype needed for their tissue incursions. We studied the effects of galectin-8 ...
MAP kinases in proliferating human colon cancer Caco-2-cells
(Springer, 2009)