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Pheromone-induced morphogenesis improves osmoadaptation capacity by activating the HOG MAPK pathway
(American Association for the Advancement of Science, 2013-04)
Environmental and internal conditions expose cells to a multiplicity of stimuli whose consequences are difficult to predict. We investigate the response to mating pheromone of yeast cells adapted to high osmolarity. Events ...
Análise da expressão das proteínas KRAS, BRAF e MEK da via de sinalização intracelular mitogen activated protein kinases (MAPK) no carcinoma hepatocelular associado a hepatopatia crônica de diferentes etiologias
(Universidade Federal de Minas GeraisBrasilMEDICINA - FACULDADE DE MEDICINAPrograma de Pós-Graduação em Ciências Aplicadas à Saúde do AdultoUFMG, 2018-08-10)
Introduction: hepatocellular carcinoma (HCC), a very aggressive cancer, common in adults, can be initiated by factors like infection with hepatitis B virus (HBV) and regeneration of the liver induced by chronic diseases. ...
Signaling pathways associated with the expression of inflammatory mediators activated during the course of two models of experimental periodontitis
(Pergamon-elsevier Science LtdOxfordInglaterra, 2009)
Mitogen-activated protein kinase is increased in the limbic structures of the rat brain during the early stages of status epilepticus
(Elsevier B.V., 1998-10-01)
Systemic administration of pilocarpine (PILO) in adult rat produces acute limbic seizures leading to states epilepticus. Recent studies have shown the activation of mitogen-activated protein kinase (MAPK) cascades during ...
How mitogen-activated protein kinases recognize and phosphorylate their targets: A QM/MM study
(American Chemical Society, 2009-05)
Mitogen-activated protein kinase (MAPK) signaling pathways play an essential role in the transduction of environmental stimuli to the nucleus, thereby regulating a variety of cellular processes, including cell proliferation, ...
Multiple giant cell lesions in patients with Noonan syndrome and cardio-facio-cutaneous syndrome
(Nature Publishing Group, 2009-04-01)
Noonan syndrome (NS) and cardio-facio-cutaneous syndrome (CFCS) are related developmental disorders caused by mutations in genes encoding various components of the RAS-MAPK signaling cascade. NS is associated with mutations ...
Pharmocologic inhibitors of the mitogen activated protein kinase cascade have the potential to interact with ionizing radiation exposure to induce cell death in carcinoma cells by multiple mechanisms
(Taylor & Francis, 2002-12)
Recent studies have shown that inhibition of stress-induced signaling via the mitogen activated protein kinase (MAPK) pathway can potentiate the toxic effects of chemotherapeutic drugs and ionizing radiation. Because of ...
Signal transduction events mediating chitosan stimulation of anthraquinone synthesis in Rubia tinctorum
(Elsevier Ireland, 2004-12)
The signalling mechanism by which chitosan increases anthraquinones in Rubia tinctorum L. is largely unknown. We recently showed that the effects of the elicitor require activation of the PLC/PKC cascade. In view of the ...
Effects of NH4Cl intake on renal growth in rats: role of MAPK signalling pathway
(Oxford Univ PressOxfordInglaterra, 2005)