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Mostrando ítems 11-20 de 122
Novel model of calcium and inositol 1,4,5-trisphosphate regulation of InsP3 receptor channel gating in native endoplasmic reticulum
(Sociedad de Biología de Chile, 2004)
Voltage-controlled gating in a large conductance Ca2+-sensitive K+ channel (hslo)
(National Academy of Sciences, 1997)
Large conductance calcium- and voltage-sensitive K+ (MaxiK) channels share properties of voltage-and ligand-gated ion channels. In voltage-gated channels, membrane depolarization promotes the displacement of charged residues ...
From hopanoids to cholesterol : molecular clocks of pentameric ligand-gated ion channels
(Elsevier, 2016)
Abstract: Pentameric ligand-gated ion channels (pLGICs) and their lipid microenvironments appear to have acquired mutually adaptive traits along evolution: 1) the three-ring architecture of their transmembrane (TM) region; ...
Ethanol's Action Mechanisms in the Brain: From Lipid General Alterations to Specific Protein Receptor Binding
(2017-02-23)
Ethanol is the most popular addictive substance used in the word. Its small and relatively simple structure facilitates its access to brain tissues and binding to many sites. This relatively unspecific action can partially ...
Caenorhabditis elegans serotonin-gated chloride channel MOD-1 as a novel drug target for anthelmintic therapy
(Sociedad Argentina de Biofísica, 2020)
Serotonin-gated ion channels (5-HT3) belong to the family of Cys-loop receptors, which are pentameric proteins that mediate fast synaptic transmission. In mammals, 5-HT3 are non-selective cationic channels that can be ...
Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors
(Bentham Science Publishers, 2005-10)
The nicotinic acetylcholine receptor (AChR) is the archetype of the Cys-loop ligand-gated ion channel'receptor superfamily. Noncompetitive antagonists inhibit the AChR without interacting directly with agonist sites. Among ...
A Novel Mechanism of Modulation of 5-HT3A Receptors by Hydrocortisone
(Cell Press, 2011-01)
Modulation of Cys-loop receptors by steroids is of physiological and therapeutical relevance. Nonetheless, its molecular mechanism has not been elucidated for serotonin (5-HT) type 3 receptors. We deciphered the mechanism ...
Nanoscale interactions between the nicotinic acetylcholine receptor and cholesterol
(Instituto de Histología y Embriología, 2021-06)
Cholesterol is a major lipid in biological membranes. It not only plays a structural role but also modulates a wide range of functional properties of neurotransmitter and hormone receptors and ion channels. The membraneembedded ...