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Participation of kallikrein-kinin system in different pathologies
(ELSEVIER SCIENCE BV, 2008)
The general description of kinins refers to these peptides as molecules involved in vascular tone regulation and inflammation. Nevertheless, in the last years a series of, evidences has shown that local hormonal systems, ...
Genetically altered animal models in the kallikrein-kinin system
(Walter de Gruyter & Co, 2006-02-01)
Transgenic and gene-targeting technologies allowing the generation of genetically altered animal models have greatly advanced our understanding of the function of specific genes. This is also true for the kallikrein-kinin ...
Kinin-B2 Receptor Mediated Neuroprotection after NMDA Excitotoxicity Is Reversed in the Presence of Kinin-B1 Receptor Agonists
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)
Background: Kinins, with bradykinin and des-Arg(9)-bradykinin being the most important ones, are pro-inflammatory peptides released after tissue injury including stroke. Although the actions of bradykinin are in general ...
Swimming training exacerbates pathological cardiac hypertrophy in kinin B(2) receptor-deficient mice
(Elsevier B.V., 2008-02-01)
Kallikrein-kinin system exerts cardioprotective effects against pathological hypertrophy. These effects are modulated mainly via B(2) receptor activation. Chronic physical exercise can induce physiological cardiac hypertrophy ...
Swimming training exacerbates pathological cardiac hypertrophy in kinin B(2) receptor-deficient mice
(Elsevier B.V., 2008-02-01)
Kallikrein-kinin system exerts cardioprotective effects against pathological hypertrophy. These effects are modulated mainly via B(2) receptor activation. Chronic physical exercise can induce physiological cardiac hypertrophy ...
The non-peptide kinin receptor antagonists FR 173657 and SSR 240612: Preclinical evidence for the treatment of skin inflammation
(Elsevier B.V., 2009-01-08)
Peptide and non-peptide kinin receptor antagonists were evaluated in cutaneous inflammation models in mice. Topical and i.p. application of kinin B(1) and B(2) receptor antagonists caused a significant inhibition of the ...
KININ: KALLIKREINS AND KININS IN CANCER
(DE GRUYTER, 2011)
Cancer is a leading cause of death, despite advances in early detection and increased understanding of cancer biology. Current cancer therapies still show limited success in improving the quality of life and life expectancy ...
KININ: KALLIKREINS AND KININS IN CANCERKINIS
(DE GRUYTER, 2016)
Modulation of B-1 and B-2 kinin receptors expression levels in the hippocampus of rats after audiogenic kindling and with limbic recruitment, a model of temporal lobe epilepsy
(ELSEVIER SCIENCE BV, 2008)
Epileptic seizures are hypersynchronous, paroxystic and abnormal neuronal discharges. Epilepsies are characterized by diverse mechanisms involving alteration of excitatory and inhibitory neurotransmission that result in ...
Kinin B-2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury
(Elsevier B.V., 2014-09-01)
Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the ...