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Distributed structures underlie gating differences between the K in Channel KAT1 and the K out Channel SKOR
(Elsevier, 2010-01)
The family of voltage-gated (Shaker-like) potassium channels in plants includes both inward-rectifying (Kin) channels that allow plant cells to accumulate K+ and outward-rectifying (Kout) channels that mediate K+ efflux. ...
Localization of the K+ lock-in and the Ba2+ binding sites in a voltage-gated calcium-modulated channel: Implications for survival of K+ permeability
(The Rockefeller University, 1999)
Using Ba2
1 as a probe, we performed a detailed characterization of an external K
1 binding site located
in the pore of a large conductance Ca2
1-activated K
1 (BKCa) channel from skeletal muscle incorporated into
planar ...
Differential effects of beta 1 and beta 2 subunits on BK channel activity
(ROCKEFELLER UNIV PRESS, 2005-04)
High conductance, calcium- and voltage-activated potassium (BK) channels are widely expressed in mammals. In some tissues, the biophysical properties of BK channels are highly affected by coexpression of regulatory (beta) ...
Rational design and synthesis of selective blockers of the K2P channel TASK-3.
(2015)
K+ channels allow the selective transfer of K+ ions inside or outside of the cell. Within this
family we find K2P channels, with four transmembrane segments and two pore domains
per subunit to form a functional dimer. These ...
Molecular coupling between voltage sensor and pore opening in the Arabidopsis inward rectifier K+ channel KAT1
(ROCKEFELLER UNIV PRESS, 2003-10)
Animal and plant voltage-gated ion channels share a common architecture. They are made up of four subunits and the positive charges on helical S4 segments of the protein in animal K+ channels are the main voltage-sensing ...
Muscarinic stimulation and pinacidil produce similar facilitation of tachyarrhythmia induction in rat isolated atria
(Academic Press Ltd- Elsevier Science LtdLondonInglaterra, 2013)
Coupling of voltage-dependent gating and Ba++ block in the high-conductance, Ca++-activated K+ channel
(1987)
Voltage-dependent Ca++-activated K+ channels from rat skeletal muscle were reconstituted into planar lipid bilayers, and the kinetics of block of single channels by Ba++ were studied. The Ba++ association rate varies ...
Cilium-attached and excised patch-clamp recordings of odourant-activated Ca-dependent K channels from chemosensory cilia of olfactory receptor neurons
(2004)
It has previously been proposed that a Ca2+-dependent K + conductance is implicated in the inhibitory odourant response in rat and toad olfactory receptor neurons. Previous whole-cell and single-channel measurements on ...
Redox properties of the adenoside triphosphate-sensitive K+ channel in brain mitochondria
(WILEY-LISS, 2008)
Brain mitochondrial ATP-sensitive K+ channel (mito-K-ATP) opening by diazoxide protects against ischemic damage and excitotoxic cell death. Here we studied the redox properties of brain mito-K-ATP. Mito-K-ATP activation ...