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INGAP-related pentadecapeptide: Its modulatory effect upon insulin secretion
(Elsevier Science BvAmsterdamHolanda, 2005)
INGAP-PP effects on β-cell mass and function are related to its positive effect on islet angiogenesis and VEGFA production
(Elsevier Ireland, 2017-10)
Our aim was to determine whether islet angiogenesis and VEGFA production/release participate in the mechanism by which INGAP-PP enhances β-cell function and mass. We used two models: a) in vivo (normal rats injected with ...
Role of Islet Glucokinase, Glucose Metabolism, and Insulin Pathway in the Enhancing Effect of Islet Neogenesis-Associated Protein on Glucose-Induced Insulin Secretion
(Lippincott Williams, 2015-08)
Objective: To demonstrate the role of islet glucokinase, glucose metabolism, and intracellular insulin mediators in the enhancing effect of islet neogenesis-associated protein pentadecapeptide (INGAP-PP) on glucoseinduced ...
A new analogue of islet neogenesis associated protein with higher structural and plasma stability
(Adenine Press, 2021-01)
Islet Neogenesis Associated Protein pentadecapeptide (INGAP-PP) increases β-cell mass and function in experimental animals. A short clinical trial also yielded promising results. However, HTD4010, a new peptide derived ...