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Immunogenetic markers associated with a naturally acquired humoral immune response against an N-terminal antigen of Plasmodium vivax merozoite surface protein 1 (PvMSP-1)
(Biomed Central Ltd, 2016-06-03)
Background: Humoral immune responses against proteins of asexual blood-stage malaria parasites have been associated with clinical immunity. However, variations in the antibody-driven responses may be associated with a ...
Approaching Genetics Through the MHC Lens: Tools and Methods for HLA Research
(2021-12-02)
The current SARS-CoV-2 pandemic era launched an immediate and broad response of the research community with studies both about the virus and host genetics. Research in genetics investigated HLA association with COVID-19 ...
Impact of population admixture on the distribution of immune response co-stimulatory genes polymorphisms in a Brazilian population
(Elsevier B.V., 2015-11-01)
Co-stimulatory molecules are essential in the orchestration of immune response and polymorphisms in their genes are associated with various diseases. However, in the case of variable allele frequencies among continental ...
Understanding the genetic contribution of the Human Leukocyte Antigen sys‐ tem to common major psychiatric disorders in a world pandemic context
The human leukocyte antigen (HLA) is a complex genetic system that encodes proteins which
predominantly regulate immune/inflammatory processes. It can be involved in a variety of
immuno-inflammatory disorders ranging ...
Enhanced natural killer activity and production of pro-inflammatory cytokines in mice selected for high acute inflammatory response (AIRmax)
(Blackwell Publishing, 2007-03-01)
Strains of mice with maximal and minimal acute inflammatory responsiveness (AIRmax and AIRmin, respectively) were developed through selective breeding based on their high- or low-acute inflammatory responsiveness. Previous ...
Macrophage migration inhibitory factor (MIF): Genetic evidence for participation in early onset and early stage rheumatoid arthritis
(2013)
Macrophage migration inhibitory factor (MIF) is an upstream pro-inflammatory cytokine that is associated with the pathogenesis of autoimmune inflammatory diseases including rheumatoid arthritis (RA). Two polymorphisms in ...
Macrophage migration inhibitory factor (MIF): Genetic evidence for participation in early onset and early stage rheumatoid arthritis
(2013)
Macrophage migration inhibitory factor (MIF) is an upstream pro-inflammatory cytokine that is associated with the pathogenesis of autoimmune inflammatory diseases including rheumatoid arthritis (RA). Two polymorphisms in ...
Enhanced natural killer activity and production of pro-inflammatory cytokines in mice selected for high acute inflammatory response (AIRmax)
(Blackwell Publishing, 2007-03-01)
Strains of mice with maximal and minimal acute inflammatory responsiveness (AIRmax and AIRmin, respectively) were developed through selective breeding based on their high- or low-acute inflammatory responsiveness. Previous ...
Evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird
(Oxford University Press, 2020-02)
Over evolutionary time,pathogen challenge shapes theimmunephenotype of the host tobetterrespondtoanincipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is ...