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IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection
(The American Association of Immunologists, 2014)
Allergen-Induced Bone Marrow Eosinophilopoiesis and Airways Eosinophilic Inflammation in Leptin-Deficient ob/ob Mice
(Nature Publishing GroupNew YorkEUA, 2012)
In pulmonary paracoccidioidomycosis IL-10 deficiency leads to increased immunity and regressive infection without enhancing tissue pathology
(Public Library of ScienceSan Francisco, 2013-10-24)
BACKGROUND:
Cellular immunity is the main defense mechanism in paracoccidioidomycosis (PCM), the most important systemic mycosis in Latin America. Th1 immunity and IFN-γ activated macrophages are fundamental to ...
Role of IL-18 in overt pain-like behaviour in mice
(ELSEVIER SCIENCE BV, 2008)
There are evidences that targeting IL-18 might be beneficial to inhibit inflammatory symptoms, including hypernociception (decrease in nociceptive threshold). The mechanism of IL-18 mechanical hypernociception depends on ...
Dual role of interleukin-4 (IL-4) in pulmonary paracoccidioidomycosis: Endogenous IL-4 can induce protection or exacerbation of disease depending on the host genetic pattern
(Amer Soc Microbiology, 2004-07-01)
Resistance to paracoccidioidomycosis, the most important endemic mycosis in Latin America, is thought to be primarily mediated by cellular immunity and the production of gamma interferon. To assess the role of interleukin-4 ...
Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production
(BioMed Central, 2015)
Abstract
Introduction
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by neutrophil articular infiltration, joint pain and the progressive destruction ...
Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice
(National Academy of Sciences, 2016)
Abstract: In mammals, initial detection of olfactory stimuli is mediated by sensory neurons in the main olfactory epithelium (MOE) and the vomeronasal organ (VNO). The heterotrimeric GTP-binding protein Go is widely expressed ...
Inducible nitric oxide synthase-deficient mice show exacerbated inflammatory process and high production of both Th1 and Th2 cytokines during paracoccidioidomycosis
(ELSEVIER SCIENCE BV, 2009)
Paracoccidioidomycosis, the major systemic mycosis in Latin America, is caused by fungus Paracoccidioides brasiliensis. To analyze the influence of inducible nitric oxide synthase (iNOS) in this disease, iNOS-deficient ...