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Regulación de la funcionalidad de las células dendríticas en el tracto intestinal a través de la activación del sensor IRE1
(Universidad de Chile, 2021)
El sistema inmune intestinal está constituido por diferentes tipos celulares, que actúan
de manera coordinada para controlar finamente la inmunidad y tolerancia.
Perturbaciones en este equilibrio entre inmunidad y ...
Regulación de la función de las células dendríticas asociadas al tumor por el sensor de la respuesta a proteínas mal plegadas IRE1
(Universidad de Chile, 2022)
Las células dendríticas (DCs), en particular las DCs convencionales de tipo 1 (cDC1s), cumplen un rol crítico en la respuesta antitumoral mediada por linfocitos T CD8+. Interesantemente, el sensor de la respuesta a proteínas ...
Caracterización de la traducción IRES-dependiente del mRNA de Denguevirus; rol de la proteína PTB como ITAF
(Universidad de Chile, 2020)
Denguevirus (DENV) es un virus envuelto, con genoma de RNA, simple hebra y polaridad
positiva, que pertenece a la familia Flaviviridae. El mRNA viral tiene una estructura 5’
m7GpppN (cap), un sitio interno de reclutamiento ...
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α
(Cell Press, 2018)
© 2018 Elsevier Inc. Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a dynamic signaling network known as the unfolded protein response (UPR). IRE1α is a major UPR transducer, determining cell fate ...
Interactome screening identifies the ER luminal chaperone Hsp47 as a regulator of the unfolded protein response transducer IRE1 alpha
(Cell Press, 2018)
Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a dynamic signaling network known as the unfolded protein response (UPR). IRE1a is a major UPR transducer, determining cell fate under ER stress. We ...
Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor
(Nature Publishing Group, 2018)
© 2018, The Author(s). Cyclosporine, a widely used immunosuppressant in organ transplantation and in treatment of various autoimmune diseases, activates the unfolded protein response (UPR), an ER stress coping response. ...
The unfolded protein response and cell fate control
(Cell Press, 2018)
The secretory capacity of a cell is constantly challenged by physiological demands and pathological perturbations. To adjust and match the protein-folding capacity of the endoplasmic reticulum (ER) to changing secretory ...
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α
(2012)
Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the unfolded protein response (UPR) stress sensor inositol-requiring enzyme 1α(IRE1α), which functions as an endoribonuclease that splices the ...
PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response
(Nature, 2015)
The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). UPR can facilitate the restoration of cellular homeostasis, via the concerted ...
IRE1 signaling exacerbates Alzheimer's disease pathogenesis
(Springer, 2017)
Altered proteostasis is a salient feature of Alzheimer's disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress and abnormal protein aggregation. ER stress triggers the activation of the unfolded ...