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Hypochlorous acid inhibition by acetoacetate: Implications on neutrophil functions
(2004-08-01)
Type-1 diabetic patients experience hyperketonemia caused by an increase in fatty acid metabolism. Thus, the aim of this study was to measure the effect of ketone bodies as suppressors of oxidizing species produced by ...
MPO Inhibitors Selected by Virtual Screening
(WILEY-BLACKWELL, 2011)
The hemeprotein myeloperoxidase (MPO) participates in innate immune defense through its ability to generate potent microbicidal oxidants. However, these oxidants are also key mediators of the tissue damage associated with ...
A novel mutation in the TPO gene in goitrous hypothyroid patients with iodide organification defect
(Blackwell Science LtdOxfordInglaterra, 1999)
Chlorogenic acid protects paraoxonase 1 activity in high density lipoprotein from inactivation caused by physiological concentrations of hypochlorite
(ELSEVIER SCIENCE BV, 2009)
We hypothesized that chlorogenic acids, the main phenolics in coffee, many fruits and Ilex paraguariensis extracts, protect paraoxonase 1 activity in HDL from inactivation by chlorination at concentrations of HOCl (50 mu ...
Inflammatory events during murine squamous cell carcinoma development
(London, 2012)
Background: Squamous cell carcinoma (SCC) is one of the most common human cancers worldwide. In SCC, tumour development is accompanied by an immune response that leads to massive tumour infiltration by inflammatory cells, ...
Oxidation of lysergic acid diethylamide (LSD) by peroxidases: a new metabolic pathway
(SPRINGERNEW YORK, 2012)
Lysergic acid diethylamide (LSD) is a potent hallucinogen that is primarily metabolized to 2-oxo-3-hydroxy-LSD (O-H-LSD) and N-desmethyl-LSD (nor-LSD) by cytochrome P450 complex liver enzymes. Due to its extensive metabolism, ...
Infection and Hyperinfection with Strongyloides stercoralis: Clinical Presentation, Etiology of Disease, and Treatment Options
(Springer, 2014)
Human strongyloidiasis is a neglected global parasitic disease that affects large populations, especially in poorer regions of the world. Improved diagnostic tools, including serology and molecular tests, are demonstrating ...