Buscar
Mostrando ítems 11-20 de 269
Towards Multidisciplinary HIV-Cure Research: Integrating Social Science with Biomedical Research
(2016)
The quest for a cure for HIV remains a timely and key challenge for the HIV research community. Despite significant scientific advances, current HIV therapy regimens do not completely eliminate the negative impact of HIV ...
Treatment of hepatitis delta and HIV infection
Hepatitis delta virus (HDV) is a defective agent that only infects individuals with hepatitis B virus (HBV). Around 5–10% of chronic hepatitis B patients worldwide are superinfected with HDV, which means 15–25 million ...
Emerging Role and Characterization of Immunometabolism: Relevance to HIV Pathogenesis, Serious Non-AIDS Events, and a Cure
(American Association of Immunologists, 2016-06)
Immune cells cycle between a resting and an activated state. Their metabolism is tightly linked to their activation status and, consequently, functions. Ag recognition induces T lymphocyte activation and proliferation and ...
Avaliação da diversidade genética e cinética de produção das formas circulares do HIV-1 em cultivo celular: impacto na manutenção da infecção viral
(Universidade Federal de São Paulo (UNIFESP), 2013-10-30)
Treatment resistant latent reservoirs remain a barrier to the HIV cure furthermore the maintenance and properties of these reservoirs are not completely understood. After HIV-1 infection, HIV-1 cDNA synthesis is initiated ...
Modeling scenarios for the end of AIDS
(Oxford University Press, 2014)
At the end of 2012, 3 decades after the human immunodeficiency virus (HIV) was first identified, neither a cure nor a fully preventive vaccine was available. Despite multiple efforts, the epidemic remains an exceptional ...
HIV Controllers Exhibit Effective CD8 + T Cell Recognition of HIV-1-Infected Non-activated CD4 + T Cells
Even with sustained antiretroviral therapy, resting CD4 + T cells remain a persistent reservoir of HIV infection, representing a critical barrier to curing HIV. Here, we demonstrate that CD8 + T cells recognize infected, ...