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Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1α S-Nitrosylation and Transcriptional Activity in Hypoxia
(2020)
Caveolin-1 (CAV1) is a well-established nitric oxide synthase inhibitor, whose function as a tumor suppressor is favored by, but not entirely dependent on, the presence of E-cadherin. Tumors are frequently hypoxic and the ...
A novel HIF-1α/VMP1-Autophagic Pathway Induces Resistance to Photodynamic Therapy in Colon Cancer Cells.
(Royal Society of Chemistry, 2017-08)
Colon cancer is the third most frequent cancer and the fourth most common cause of cancer-related mortality worldwide and the standard therapy is surgical resection plus adjuvant chemotherapy. Photodynamic therapy (PDT) ...
Immunohistochemical investigation of the angiogenic proteins VEGF, HIF-1α and CD34 in invasive ductal carcinoma of the breast
(2013-07-29)
The expression of prognostic markers in cancer has become important in diagnostic routine and research. A high mitotic rate compromises the individual cell access to oxygen and nutrients, due to reduced blood supply. Cells ...
Immunohistochemical investigation of the angiogenic proteins VEGF, HIF-1α and CD34 in invasive ductal carcinoma of the breast
(2013-07-29)
The expression of prognostic markers in cancer has become important in diagnostic routine and research. A high mitotic rate compromises the individual cell access to oxygen and nutrients, due to reduced blood supply. Cells ...
Drosophila genome-wide RNAi screen identifies multiple regulators of HIF-dependent transcription in hypoxia
(Public Library of Science, 2010-06)
Hypoxia-inducible factors (HIFs) are a family of evolutionary conserved alpha-beta heterodimeric transcription factors that induce a wide range of genes in response to low oxygen tension. Molecular mechanisms that mediate ...
Pdgf1aa regulates zebrafish neural crest cells migration through Hif-1 in an oxygen-independent manner
(2018)
The transcription factor Hif-1 alpha regulates epithelial to mesenchymal transition and neural crest cell chemotaxis in Xenopus. Hif-1 alpha is only stabilised under low oxygen levels, and the in vivo stabilisation of this ...
Immunohistochemical Expression Of Glut-1 And Hif-1 In Tooth Germ, Ameloblastoma, And Ameloblastic Carcinoma
(SAGE PUBLICATIONS INCTHOUSAND OAKS, 2016)
La estabilización de HIF-1α induce la expresión de GEFS claves para la activación de RAB5
(Universidad de Chile, 2019)
INTRODUCCIÓN: Estudios previos de nuestro laboratorio evidenciaron que la GTPasa pequeña
Rab5 promueve la adquisición y mantención de características de malignidad tumoral en condiciones
de hipoxia, lo cual pareciera ser ...
Immunohistochemical Expression Of Glut-1 And Hif-1 In Yooth Germ, Ameloblastoma, And Ameloblastic Carcinoma
(Sage Publications IncTHOUSAND OAKS, 2016)