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Analysis of the SARS‑CoV‑2 spike protein glycan shield reveals implications for immune recognition
Here we have generated 3D structures of glycoforms of the spike (S) glycoprotein from SARS-CoV-2,
based on reported 3D structures and glycomics data for the protein produced in HEK293 cells. We
also analyze structures ...
Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer
(Cell Press, 2012-03)
Numerous regulatory programs have been identified that contribute to the restoration of homeostasis at the conclusion of immune responses and to safeguarding against the detrimental effects of chronic inflammation and ...
CheSweet: An application to predict glycan’s chemicals shifts
(NumFOCUS, 2018-01)
Glycans are the most abundant and structurally diverse biomolecules in nature. The knowledge of the tridimensional structure of glycans is necessary to understand in detail, at atomic level, the molecular processes in which ...
CheSweet: An application to predict glycan's chemicals shifts
(Journal of Open Source Software, 2018-01)
The knowledge of the tridimensional structure of glycans is necessary to understand in detail, at atomic level, the molecular processes in which they are involved. Chemical Shifts (CS) are observables obtained from Nuclear ...
Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the difference
(Landes Bioscience, 2014-06-25)
Although blocking vascular endothelial growth factor (VEGF) signaling is clinically beneficial in certain cancers, tumor regrowth in treated patients suggests that compensatory angiogenic programs may limit the efficacy ...
Pregnancy galectinology: Insights into a complex network of glycan binding proteins
(Frontiers Media S.A., 2019-05)
Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast ...
Molecular strategies and interactions between representative bacteria of the human gut microbiota during the utilization of glycomacropeptide
(2024)
The human gut microbiota plays an essential role in metabolizing complex dietary compounds that host enzymes cannot degrade. The prebiotic role of milk glycans, such as free human milk oligosaccharides (HMO), currently ...
Modulation of Dendritic Cell Maturation by Fasciola hepatica: Implications of Glycans and Mucins for Vaccine Development
(OMICS Publlishing group, 2014-06)
Fasciola hepatica is a worldwide distributed helminth pathogen that causes great economic losses in sheep andcattle. This parasite is able to regulate the host immune response, producing high levels of IL-5 and low levels ...
Glycans in Glycoprotein Quality Control
(Cold Spring Harbor Laboratory Press, 2009)
Nglycans help glycoproteins fold by creating a series of checkpoints that dictate the life or the death of newly made membrane and secreted proteins. This chapter describes the quality control process in the endoplasmic ...
Glycans pave the way for immunotherapy in triple-negative breast cancer
(Cell Press, 2018-02)
The clinical efficacy of therapies targeting the PD-1/PD-L1 pathway is still limited. In this issue of Cancer Cell, Li and colleagues identify a PD-L1 glycosylation-based mechanism in triple-negative breast cancer that ...