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Excitotoxic neonatal damage induced by monosodium glutamate reduces several GABAergic markers in the cerebral cortex and hippocampus in adulthood
(2009)
Monosodium glutamate (MSG) administered to neonatal rats during the first week of life induces a neurodegenerative process, which is represented by several neurochemical alterations of surviving neurons in the brain, where ...
The role of polar phytocomplexes on anticonvulsant effects of leaf extracts of Lippia alba (Mill.) NE Brown chemotypes
(PHARMACEUTICAL PRESS-ROYAL PHARMACEUTICAL SOC GREAT BRITIAN, 2009)
Objectives The purpose of the present work was to characterize file pharmacological profile of different L. alba chemotypes and to correlate the obtained data to the presence of chemical constituents detected by phytochemical ...
Characterization of the actions of AvTx 7 isolated from Agelaia vicina (Hymenoptera : Vespidae) wasp venom on synaptosomal glutamate uptake and release
(Wiley-Blackwell, 2004-01-01)
It has previously been shown that the denatured crude extract of Agelaia vicina wasp venom inhibits glutamate and GABA uptake in rat cerebral cortex synaptosomes. To identify the components responsible for these effects, ...
Effects of chronic modafinil treatment in young rats on social behaviour and dopaminergic neurotransmission
(2020)
Modafinil (MOD) is an atypical stimulant used to enhance wakefulness and vigilance. The mechanism of action of MOD includes the blockage of dopamine (DA) and norepinephrine (NE) transporters (DAT and NET, respectively). ...
Efeito do tipo antidepressivo do 7-flúor-1,3-difenilisoquinolina-1-amina em modelos de estresse em roedores
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaCentro de Ciências Naturais e Exatas, 2018-03-23)
Current treatments for depression are inadequate for many patients and progress in understanding of this psychiatric disease is slow. The isoquinoline is an important class of molecules with antidepressant-like effect in ...
Effects of chronic modafinil treatment in young rats on social behavior and dopaminergic neurotransmission
(Universidad de Valparaíso, 2020-11)
Modafinil (MOD) is an atypical stimulant used to enhance wakefulness and vigilance. The mechanism of action of MOD includes the blockage of dopamine (DA) and norepinephrine (NE) transporters (DAT and NET, respectively). ...
Ação farmacológica do 3-alquinil selenofeno em modelos de convulsão em ratos jovens
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2012-03-02)
Seizures have important consequences in terms of mortality and quality of life of the affected population, being a risk factor for the development of cognitive and behavioral abnormalities. Considering the promising ...
Sodium Potassium Chloride co-transporter 1 (NKCC1) is responsible of high excitability in chronic epilepsy in adult rats
(2015)
The increase in hippocampal excitability is one of the cardinal symptoms of temporal lobe epilepsy (TLE), the most common
epilepsy type. In epileptic patients as well as animal models have been observed an increase in ...
Novel function of transcription factor Uga3 as an activator of branched-chain amino acid permease BAP2 gene expression
(Society for General Microbiology, 2019-10)
Transcription regulation of most genes in yeast occurs at the level of activation, i.e. the basal level of expression is very low and increased transcription requires gene-specific transcription factors allowing the ...