Buscar
Mostrando ítems 11-20 de 1061
Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain
(Biomed Central LtdLondonInglaterra, 2011)
Tyrosine 251 at the C-terminus of Neuronal Glycoprotein M6a is Critical for Neurite Outgrowth
(Wiley-liss, Div John Wiley & Sons Inc, 2015-09)
Neuronal glycoprotein M6a is involved in neuronal plasticity, promoting neurite and filopodia outgrowth and, likely, synaptogenesis. Polymorphisms in the human M6a gene GPM6A have recently been associated with mental ...
Specificity evolution of the ADP-dependent sugar kinase family - in silico studies of the glucokinase/phosphofructokinase bifunctional enzyme from Methanocaldococcus jannaschii
(2008)
In several archaea of the Euryarchaeota, the glycolytic flux proceeds through a modified version of the Embden-Meyerhof pathway, where the phosphofructokinase and glucokinase enzymes use ADP as the phosphoryl donor. These ...
Differentiation of C2C12 myoblasts is critically regulated by FAK signaling
(Amer Physiological SocBethesdaEUA, 2005)
Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol
(2002-07-08)
Flavopiridol has been shown to potently inhibit CDK1 and 2 (cyclin-dependent kinases 1 and 2) and most recently it has been found that it also inhibits CDK9. The complex CDK9-cyclin T1 controls the elongation phase of ...
Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol
(2002-07-08)
Flavopiridol has been shown to potently inhibit CDK1 and 2 (cyclin-dependent kinases 1 and 2) and most recently it has been found that it also inhibits CDK9. The complex CDK9-cyclin T1 controls the elongation phase of ...
Insights into the inhibitory effect of Ca2+ on protein kinase A from molecular dynamics simulations.
(2016)
Abstract: Protein kinases are an important family of enzymes that govern many signaling processes within cells by transferring a phosphoryl group from an ATP molecule onto a substrate protein. cAMP-dependent protein kinase, ...
Assessing the effect of calcium and magnesium ions in the structural stability of the protein kinase A through molecular dynamics simulations
(2017)
Protein kinase A (PKA) is part of the big family of protein kinases, whose role consists in
catalyzing the transfer of a phosphate group from an ATP molecule to a peptide substrate. While
Mg2+ is the preferred cofactor in ...
Emergence of pyridoxal phosphorylation through a promiscuous ancestor during the evolution of hydroxymethyl pyrimidine kinases
(Elsevier, 2014)
In the family of ATP-dependent vitamin kinases, several bifunctional enzymes that phosphorylate
hydroxymethyl pyrimidine (HMP) and pyridoxal (PL) have been described besides enzymes specific
towards HMP. To determine how ...