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AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCK cells
(NATL ACAD SCIENCES, 2007)
The epithelial-specific adaptor AP1B sorts basolateral proteins, but the trafficking routes where it performs its sorting role remain controversial. Here, we used an RNAi approach to knock down the medium subunit of AP1B ...
The normal chain length distribution of the O antigen is required for the interaction of Shigella flexneri 2a with polarized Caco-2 cells
(2012)
Shigella flexneri causes bacillary dysentery in humans. Essential to the establishment of the disease is the invasion of the colonic epithelial cells. Here we investigated the role of the lipopolysaccharide (LPS) O antigen ...
Human papillomavirus (HPV)-18 E6 oncoprotein interferes with the epithelial cell polarity Par3 protein
(Elsevier, 2014-01)
High-risk human papillomavirus (HPV) infection is the principal risk factor for the development of cervical cancer. The HPV E6 oncoprotein has the ability to target and interfere with several PSD-95/DLG/ZO-1 (PDZ) ...
Sjögren's syndrome and the epithelial target: A comprehensive review
(2013)
The most difficult component in our understanding of human autoimmunity remains a rigorous dissection of etiological events. Indeed, the vast literature on autoimmune diseases focuses on the inflammatory response, with the ...
Microtubules regulate brush border formation
(Wiley-liss, Div John Wiley & Sons Inc, 2018-02)
Most epithelial cells contain apical membrane structures associated to bundles of actin filaments, which constitute the brush border. Whereas microtubule participation in the maintenance of the brush border identity has ...
A long-term in vitro culture of bovine epithelial cells on collagen rafts
(Wiley Blackwell Publishing, Inc, 2021-02)
In the present work, we established and characterized a 3D functional polarized primary bovine oviduct epithelial cells (BOECs) culture on free-floating type I collagen hydrogels (rafts) at an air-liquid interface (ALI). ...
Glycans in post-Golgi apical targeting: sorting signals or structural props?
(ELSEVIER SCIENCE LONDON, 1999)
A recent model proposed that N-glycans serve as apical targeting signals for soluble and membrane proteins in epithelial cells and neurons by interacting with lectin sorters in the trans-Golgi network. However, we believe ...
Castration-induced prostate epithelial cell apoptosis results from targeted oxidative stress attack of M1(142)-macrophages
(Wiley-Blackwell, 2019-10-01)
Prostate development and function are regulated by androgens. Epithelial cell apoptosis in response to androgen deprivation is caspase-9-dependent and peaks at Day 3 after castration. However, isolated epithelial cells ...