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Hyperosmotic stress promotes endoplasmic reticulum stress‑dependent apoptosis in adult rat cardiac myocytes
(Springer, 2019-07-15)
In diferent pathological situations, cardiac cells undergo hyperosmotic stress and cell shrinkage. This change in cellular volume has been associated with contractile dysfunction and cell death. However, the intracellular ...
Pre-Pregnancy Maternal Obesity Associates With Endoplasmic Reticulum Stress In Human Umbilical Vein Endothelium
(2018)
Obesity associates with the endoplasmic reticulum (ER) stress-induced endothelial dysfunction. Pregnant women with pre-pregnancy maternal obesity (PGMO) may transfer this potential risk to their offspring; however, whether ...
Converging pathways in the occurrence of endoplasmic reticulum (er) stress in Huntington's disease
(2011)
A variety of neurological diseases including Huntington's disease (HD), Alzheimer's disease and Parkinson's disease share common neuropathology, primarily featuring the presence of abnormal protein inclusions containing ...
Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress
(2019)
Close contacts between endoplasmic reticulum and mitochondria enable reciprocal Ca2+ exchange, a key mechanism in the regulation of mitochondrial bioenergetics. During the early phase of endoplasmic reticulum stress, this ...
Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics
(Elsevier, 2012)
Endoplasmic reticulum (ER) stress activates an adaptive unfolded protein response (UPR) that facilitates
cellular repair, however, under prolonged ER stress, the UPR can ultimately trigger apoptosis thereby terminating
damaged ...
Endoplasmic reticulum calcium signaling in nerve cells
(Sociedad de Biología de Chile, 2004)
Non-immune mechanisms of muscle damage in myositis: Role of the endoplasmic reticulum stress response and autophagy in the disease pathogenesis
(Lippincott, Williams & Wilkins, 2018)
Chlorhexidine-induced apoptosis or necrosis in L929 fibroblasts: A role for endoplasmic reticulum stress
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009)
Chlorhexidine (CHX), widely used as antiseptic and therapeutic agent in medicine and dentistry, has a toxic effect both in vivo and in vitro. The intrinsic mechanism underlying CHX-induced cytotoxicity in eukaryotic cells ...
Endoplasmic Reticulum Stress and the Hallmarks of Cancer
(2016)
Tumor cells are often exposed to intrinsic and external factors that alter protein homeostasis, thus producing endoplasmic reticulum (ER) stress. To cope with this, cells evoke an adaptive mechanism to restore ER proteostasis ...
The unfolded protein response: at the intersection between endoplasmic reticulum function and mitochondrial bioenergetics
(Frontiers Media, 2017)
Endoplasmic reticulum (ER) to mitochondria communication has emerged in recent years as a signaling hub regulating cellular physiology with a relevant contribution to diseases including cancer and neurodegeneration. This ...