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Regulation of drug prices in nineteenth-century Bazilian pharmacy
(Fundaco Oswaldo Cruz, 2020-07-01)
On November 5th, 1808, D. Joao de Braganca issued a license about the practice of druggists and the price of drugs and ordered the creation of a regulation to tax the cost of medicines marketed in Brazil. First published ...
MicroRNA expression is differentially altered by xenobiotic drugs in different human cell lines
(WILEY-BLACKWELL, 2011)
Several noncoding microRNAs (miR or miRNA) have been shown to regulate the expression of drug-metabolizing enzymes and transporters. Xenobiotic drug-induced changes in enzyme and transporter expression may be associated ...
"Review: Application of Bioequivalence Testing of Medicines in Peru"
(Dissolution Technologies IncUS, 2022-11)
"This is a review of the current status of drug bioequivalence studies in Peru. A bibliographic search was conducted in
PubMed (Medline database) for bioequivalence studies in Peru. Generic drugs constitute the basis of ...
Brazilian Regulation in Drug Surveillance
(Adis Int Ltd, 2017-10-01)
AGC kinases, mechanisms of regulation and innovative drug development
(Academic Press Ltd - Elsevier Science Ltd, 2018-02)
The group of AGC kinases consists of 63 evolutionarily related serine/threonine protein kinases comprising PDK1, PKB/Akt, SGK, PKC, PRK/PKN, MSK, RSK, S6K, PKA, PKG, DMPK, MRCK, ROCK, NDR, LATS, CRIK, MAST, GRK, Sgk494, ...
Acute regulation of apical ABC transporters in the gut. Potential influence on drug bioavailability
(Academic Press Ltd - Elsevier Science Ltd, 2021-01)
The extensive intestinal surface offers an advantage regarding nutrient, ion and water absorptive capacity but also brings along a high exposition to xenobiotics, including drugs of therapeutic use and food contaminants. ...
Drug Transporters
(Springer Nature Switzerland AG, 2018)
Membrane transporters perform a central function in many essential body functions, including traffic and compartmentalization of physiologic compounds, absorption of physiologic compounds (and, occasionally, structurally ...
Molecular hybridization: A useful tool in the design of new drug prototypes
(2007-07-01)
Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hyrid compound with improved affinity and ...