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Mostrando ítems 11-20 de 250
In silico REPOSITIONING OF NEW DRUGS AGAINST Schistosoma mansoni
(Universidade Federal de Goiás, 2018)
Multi-target pharmacology: Possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective
(Frontiers Research Foundation, 2015-09)
Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance issues. Prospective drug repositioning ...
Drug repositioning based on the reversal of gene expression signatures identifies top2a as a therapeutic target for rectal cancer
(2021-11-01)
Rectal cancer is a common disease with high mortality rates and limited therapeutic options. Here we combined the gene expression signatures of rectal cancer patients with the reverse drug-induced gene-expression profiles ...
How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
(Smart Science & Technology, 2014-02)
Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of ...
Repositioning of Anti-parasitic Drugs in Cyclodextrin Inclusion Complexes for Treatment of Triple-Negative Breast Cancer
(Springer, 2018-11)
Drug repositioning refers to the identification of new therapeutic indications for drugs already approved. Albendazole and ricobendazole have been used as anti-parasitic drugs for many years; their therapeutic action is ...
Redirecionamento de fármacos e sinergia de medicamentos não-antibióticos e antibióticos no tratamento de doenças infecciosas
(Universidade Federal de Santa MariaBrasilAnálises Clínicas e ToxicológicasUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2018-09-13)
The indiscriminate use of antimicrobials in monotherapy has led to the emergence of
multiresistant bacterial strains, which are also one of the greatest threats to human health.
Whiles antibiotic resistance presents ...